Sialidase: Difference between revisions
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== Function == | == Function == | ||
''' | '''Sialidase''' is a neuraminidase which cleaves terminal sialic acid from a variety of natural substances <ref>PMID:12374200</ref>. '''Trans-sialidase''' is a modified sialidase which has transglycosidase activity and transfers sialic acid from host glycoconjugates to β-galactose on a parasite surface<ref>PMID:15588836</ref>, <ref>PMID:8405811</ref>. | ||
== Disease == | == Disease == | ||
== Relevance == | == Relevance == | ||
''Trypanosoma cruzi'' trans-sialidase is a drug target agains Chagas Disease<ref>PMID:24144418</ref>. | |||
== Structural highlights == | == Structural highlights == | ||
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**[[3b69]], [[1ms0]], [[1ms1]], [[1ms5]], [[1ms8]] - TcSal (mutant) + neuraminic acid derivative<br /> | **[[3b69]], [[1ms0]], [[1ms1]], [[1ms5]], [[1ms8]] - TcSal (mutant) + neuraminic acid derivative<br /> | ||
**[[3opz]] - TcSal (mutant) + antibody<br /> | **[[3opz]] - TcSal (mutant) + antibody<br /> | ||
**[[1sli]], [[2sli]], [[3sli]], [[4sli]] - | **[[1sll]] – lSal L - leech<br /> | ||
**[[1sli]], [[2sli]], [[3sli]], [[4sli]] - lSal + neuraminic acid derivative <br /> | |||
**[[4x47]], [[4x4a]] - RgSal + neuraminic acid derivative - ''Ruminococcus gnavus''<br /> | **[[4x47]], [[4x4a]] - RgSal + neuraminic acid derivative - ''Ruminococcus gnavus''<br /> | ||
**[[4x49]] - RgSal + tamiflu<br /> | **[[4x49]] - RgSal + tamiflu<br /> | ||
