Sialidase

spinqualitylabelsall models Caption for this structure Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image   Print3D Function Sialidase is a neuraminidase which cleaves terminal sialic acid from a variety of natural substances . For Trans-sialidase see Neuraminidase. Anhydrosialidase catalyzes the elimination of sialyl group in N-acetylneuraminic acid glycosides to yield 2,7-anhydro-α-N-acetylneuraminate. Relevance Trypanosoma cruzi trans-sialidase is a drug target agains Chagas Disease.

3D structures of salidase

Updated on 07-November-2018

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• Salidase
  • Neuraminidase - MvNANA residues 43-407 – Micromonospora viridifaciens
    
  • 1euu - MvNANA residues 47-647
    
  • 1wcq, 1w8n, 1w8o, 2hu0, 2hu4 – MvNANA residues 47-647 (mutant)
    
  • 5mqr, 5mqs, 4bbw, 5muk, 5mul - BtSal - Bacterioides thetaiotaomicron
    
  • 1mz5, 1n1s - TrSal - Trypanosoma rangeli
    
  • 1wcs - TrSal (mutant)
    
  • 3sil – StSal (mutant) – Salmonella typhimurium
    
  • 1snt, 1so7 – hSal2 - human
    
  • 2f24, 2f26, 2f28 – hSal2 (mutant)
    
  • 2w20 – SpSal A catalytic domain - Streptococcus pneumoniae
    
  • 4zxk – SpSal A CBD
    
  • 2vw0, 2vw2, 4xik, 2ya4, 2w20, 2vvz, 3h71 - SpSal B
    
  • 4xmi, 4xio, 4xj8, 4xma, 4xjz, 4xik - SpSal B (mutant)
    
  • 4yw4 – SpSal C
    
  • 2xzi, 2xzj, 2xzk, 2xcy – AfSal – Aspergillus fumigatus
    
  • 4m4n, 4m4u - AfSal (mutant)
    
  • 1sll – Sal L - leech
    
  • 2vk5, 5tsp - CpSal I – Clostridium perfringens
    
• Salidase complexes
  • 2w68 – VcSal CBD + sialic acid – Vibrio cholerae
    
  • 1kit– VcSal + sialic acid
    
  • 1w0p – VcSal + sialic acid derivative
    
  • 6eks, 6eku – VcSal + drug
    
  • 3h72, 2ya5 – SpSal A + sialic acid
    
  • 4c1w, 4c1x – SpSal A CBD + sialic acid derivative
    
  • 2ya7, 2ya8, 5kky, 5f9t, 2ya6, 2jkb - SpSal A catalytic domain + drug
    
  • 2vvz, 3h73 – SpSal A + neuraminic acid derivative
    
  • 2vw1 – SpSal B + neuraminic acid derivative
    
  • 4xyx – SpSal B + drug
    
  • 4xog, 4xjw, 4xj9, 4xil, 4xe9 – SpSal B (mutant) + drug
    
  • 4foq, 4fov, 4fow, 4foy, 4fp2, 4fp3, 4fpc, 4fpe, 4fpf, 4fpg, 4fph, 4fpj, 4fpk, 4fpl, 4fpo, 4fpy, 4fq4 – SpSal B + inhibitor
    
  • 4xju, 4xja, 4xhx, 4xhb – SpSal B (mutant) + inhibitor
    
  • 2jkb – SpSal B + sialic acid derivative
    
  • 4yz3, 4yw5 – SpSal C + drug
    
  • 4yw2 – SpSal C + sialic acid
    
  • 4yz4, 4yz2 – SpSal C + neuraminic acid derivative
    
  • 4yw1, 4yw3 – SpSal C + sialic acid + neuraminic acid derivative
    
  • 1w0o – VcSal + sialic acid + neuraminic acid derivative
    
  • 2vk6, 2vk7 – CpSal I + neuraminic acid derivative
    
  • 2bf6 – CpSal I residues 243-691 + sialic acid
    
  • 5fra, 5fre – CpSal I CBD + sialic acid
    
  • 2v73– CpSal J CBD + sialic acid
    
  • 2v72– CpSal J CBD + galactose
    
  • 1n1v – TrSal + neuraminic acid derivative
    
  • 1mz6, 1n1t, 2ags – TrSal + inhibitor
    
  • 1n1y– TrSal + sialic acid
    
  • 2a75, 2fhr – TrSal + sialic acid derivative
    
  • 1dim, 1dil, 2sil, 2sim – StSal + inhibitor
    
  • 1eus - MvSal residues 43-407 + neuraminic acid derivative
    
  • 1eut - MvSal residues 47-647 + galactose
    
  • 2bzd - MvSal residues 47-647 (mutant) + galactose
    
  • 1w80 - MvSal residues 47-647 (mutant) + lactose
    
  • 1wcq, 1w8n – MvSal (mutant) + neuraminic acid derivative
    
  • 2ber – MvSal (mutant) + sialic acid derivative
    
  • 4m4v – AfSal (mutant) + neuraminic acid derivative
    
  • 1vcu, 2f0z, 2f10, 2f11, 2f12, 2f13 - hSal2 + inhibitor
    
  • 2f25, 2f27, 2f29, 4nc5, 4ncs - hSal2 (mutant) + inhibitor
    
  • 5mul – BtSal + glucuronic acid
    
• Trans-sialidase
  • 1mr5, 1ms3, 1ms4 - TcSal (mutant) - Trypanosoma cruzi
    
  • 1ms9, 1s0i, 3pjq - TcSal (mutant) + lactose derivative
    
  • 1s0j, 2ah2 - TcSal (mutant) + sialic acid derivative
    
  • 3b69, 1ms0, 1ms1, 1ms5, 1ms8 - TcSal (mutant) + neuraminic acid derivative
    
  • 3opz - TcSal (mutant) + antibody
    
  • 1sll – lSal L - leech
    
  • 1sli, 2sli, 3sli, 4sli - lSal + neuraminic acid derivative
    
  • 4x47, 4x4a - RgSal + neuraminic acid derivative - Ruminococcus gnavus
    
  • 4x49 - RgSal + tamiflu
    
  • 4x6k - RgSal + siastatin
    

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