Sialidase: Difference between revisions
From Proteopedia
Jump to navigationJump to search
Michal Harel (talk | contribs) No edit summary |
Michal Harel (talk | contribs) No edit summary |
||
| Line 1: | Line 1: | ||
<StructureSection load=' | <StructureSection load='2w68' size='340' side='right' caption='Caption for this structure' scene=''> | ||
== Function == | == Function == | ||
'''Sialidase''' is a neuraminidase which cleaves terminal sialic acid from a variety of natural substances <ref>PMID:12374200</ref>. | '''Sialidase''' is a neuraminidase which cleaves terminal sialic acid from a variety of natural substances <ref>PMID:12374200</ref>. The sialic acid-binding domain of sialidase is called CBD. For '''Anhydrosialidase''' catalyzes the elimination of sialyl group in N-acetylneuraminic acid glycosides to yield 2,7-anhydro-α-N-acetylneuraminate. For '''Trans-sialidase''' see [[Neuraminidase]]. | ||
== Disease == | == Disease == | ||
== Relevance == | == Relevance == | ||
== Structural highlights == | == Structural highlights == | ||
| Line 70: | Line 68: | ||
**[[1n1v]] – TrSal + neuraminic acid derivative <br /> | **[[1n1v]] – TrSal + neuraminic acid derivative <br /> | ||
**[[1mz6]], [[1n1t]], [[2ags]] – TrSal + inhibitor <br /> | **[[1mz6]], [[1n1t]], [[2ags]] – TrSal + inhibitor <br /> | ||
**[[1n1y]]– TrSal + sialic acid <br /> | **[[1n1y]] – TrSal + sialic acid <br /> | ||
**[[2a75]], [[2fhr]] – TrSal + sialic acid derivative<br /> | **[[2a75]], [[2fhr]] – TrSal + sialic acid derivative<br /> | ||
**[[1dim]], [[1dil]], [[2sil]], [[2sim]] – StSal + inhibitor <br /> | **[[1dim]], [[1dil]], [[2sil]], [[2sim]] – StSal + inhibitor <br /> | ||
