2v5o: Difference between revisions
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{{STRUCTURE_2v5o| PDB=2v5o | SCENE= }} | |||
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'''STRUCTURE OF HUMAN IGF2R DOMAINS 11-14''' | '''STRUCTURE OF HUMAN IGF2R DOMAINS 11-14''' | ||
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[[Category: Wallace, J C.]] | [[Category: Wallace, J C.]] | ||
[[Category: Zaccheo, O J.]] | [[Category: Zaccheo, O J.]] | ||
[[Category: | [[Category: Beta barrel]] | ||
[[Category: | [[Category: Cation independent mannose 6-phosphate]] | ||
[[Category: | [[Category: Fibronectin type ii]] | ||
[[Category: | [[Category: Glycoprotein]] | ||
[[Category: | [[Category: Insulin-like growth factor]] | ||
[[Category: | [[Category: Lysosome]] | ||
[[Category: | [[Category: Membrane]] | ||
[[Category: | [[Category: Phosphorylation]] | ||
[[Category: | [[Category: Polymorphism]] | ||
[[Category: | [[Category: Receptor]] | ||
[[Category: | [[Category: Transmembrane]] | ||
[[Category: | [[Category: Transport]] | ||
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Revision as of 06:30, 24 April 2008
STRUCTURE OF HUMAN IGF2R DOMAINS 11-14
Overview
Embryonic development and normal growth require exquisite control of insulin-like growth factors (IGFs). In mammals the extracellular region of the cation-independent mannose-6-phosphate receptor has gained an IGF-II-binding function and is termed type II IGF receptor (IGF2R). IGF2R sequesters IGF-II; imbalances occur in cancers and IGF2R is implicated in tumour suppression. We report crystal structures of IGF2R domains 11-12, 11-12-13-14 and domains 11-12-13/IGF-II complex. A distinctive juxtaposition of these domains provides the IGF-II-binding unit, with domain 11 directly interacting with IGF-II and domain 13 modulating binding site flexibility. Our complex shows that Phe19 and Leu53 of IGF-II lock into a hydrophobic pocket unique to domain 11 of mammalian IGF2Rs. Mutagenesis analyses confirm this IGF-II 'binding-hotspot', revealing that IGF-binding proteins and IGF2R have converged on the same high-affinity site.
About this Structure
2V5O is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.
Reference
Structure and functional analysis of the IGF-II/IGF2R interaction., Brown J, Delaine C, Zaccheo OJ, Siebold C, Gilbert RJ, van Boxel G, Denley A, Wallace JC, Hassan AB, Forbes BE, Jones EY, EMBO J. 2008 Jan 9;27(1):265-76. Epub 2007 Nov 29. PMID:18046459 Page seeded by OCA on Thu Apr 24 09:30:03 2008
Proteopedia Page Contributors and Editors (what is this?)
- Pages with broken file links
- Homo sapiens
- Single protein
- Boxel, G Van.
- Brown, J.
- Delaine, C.
- Denley, A.
- Forbes, B E.
- Gilbert, R J.
- Hassan, A B.
- Jones, E Y.
- Siebold, C.
- Wallace, J C.
- Zaccheo, O J.
- Beta barrel
- Cation independent mannose 6-phosphate
- Fibronectin type ii
- Glycoprotein
- Insulin-like growth factor
- Lysosome
- Membrane
- Phosphorylation
- Polymorphism
- Receptor
- Transmembrane
- Transport
