2v61: Difference between revisions

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[[Image:2v61.gif|left|200px]]
[[Image:2v61.gif|left|200px]]


{{Structure
<!--
|PDB= 2v61 |SIZE=350|CAPTION= <scene name='initialview01'>2v61</scene>, resolution 1.70&Aring;
The line below this paragraph, containing "STRUCTURE_2v61", creates the "Structure Box" on the page.
|SITE= <scene name='pdbsite=AC1:Fad+Binding+Site+For+Chain+A'>AC1</scene>, <scene name='pdbsite=AC2:C18+Binding+Site+For+Chain+A'>AC2</scene>, <scene name='pdbsite=AC3:Fad+Binding+Site+For+Chain+B'>AC3</scene> and <scene name='pdbsite=AC4:C18+Binding+Site+For+Chain+B'>AC4</scene>
You may change the PDB parameter (which sets the PDB file loaded into the applet)  
|LIGAND= <scene name='pdbligand=C18:7-[(3-CHLOROBENZYL)OXY]-4-[(METHYLAMINO)METHYL]-2H-CHROMEN-2-ONE'>C18</scene>, <scene name='pdbligand=FAD:FLAVIN-ADENINE+DINUCLEOTIDE'>FAD</scene>
or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
|ACTIVITY= <span class='plainlinks'>[http://en.wikipedia.org/wiki/Amine_oxidase_(flavin-containing) Amine oxidase (flavin-containing)], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.4.3.4 1.4.3.4] </span>
or leave the SCENE parameter empty for the default display.
|GENE=  
-->
|DOMAIN=
{{STRUCTURE_2v61| PDB=2v61  | SCENE= }}  
|RELATEDENTRY=[[1gos|1GOS]], [[1h8r|1H8R]], [[1oj9|1OJ9]], [[1oja|1OJA]], [[1ojb|1OJB]], [[1ojc|1OJC]], [[1ojd|1OJD]], [[1s2q|1S2Q]], [[1s2y|1S2Y]], [[1s3b|1S3B]], [[1s3e|1S3E]], [[2bk3|2BK3]], [[2bk4|2BK4]], [[2bk5|2BK5]], [[2byb|2BYB]], [[2c64|2C64]], [[2c65|2C65]], [[2c66|2C66]], [[2c67|2C67]], [[2c70|2C70]], [[2c72|2C72]], [[2c73|2C73]], [[2c75|2C75]], [[2c76|2C76]], [[2v5z|2V5Z]], [[2v60|2V60]]
|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2v61 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2v61 OCA], [http://www.ebi.ac.uk/pdbsum/2v61 PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=2v61 RCSB]</span>
}}


'''STRUCTURE OF HUMAN MAO B IN COMPLEX WITH THE SELECTIVE INHIBITOR 7-(3-CHLOROBENZYLOXY)-4-(METHYLAMINO)METHYL-COUMARIN'''
'''STRUCTURE OF HUMAN MAO B IN COMPLEX WITH THE SELECTIVE INHIBITOR 7-(3-CHLOROBENZYLOXY)-4-(METHYLAMINO)METHYL-COUMARIN'''
Line 23: Line 20:
==Reference==
==Reference==
Structures of human monoamine oxidase B complexes with selective noncovalent inhibitors: safinamide and coumarin analogs., Binda C, Wang J, Pisani L, Caccia C, Carotti A, Salvati P, Edmondson DE, Mattevi A, J Med Chem. 2007 Nov 15;50(23):5848-52. Epub 2007 Oct 4. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/17915852 17915852]
Structures of human monoamine oxidase B complexes with selective noncovalent inhibitors: safinamide and coumarin analogs., Binda C, Wang J, Pisani L, Caccia C, Carotti A, Salvati P, Edmondson DE, Mattevi A, J Med Chem. 2007 Nov 15;50(23):5848-52. Epub 2007 Oct 4. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/17915852 17915852]
[[Category: Amine oxidase (flavin-containing)]]
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
[[Category: Single protein]]
[[Category: Single protein]]
Line 34: Line 30:
[[Category: Salvati, P.]]
[[Category: Salvati, P.]]
[[Category: Wang, J.]]
[[Category: Wang, J.]]
[[Category: fad]]
[[Category: Fad]]
[[Category: flavoprotein]]
[[Category: Flavoprotein]]
[[Category: human mao b structure]]
[[Category: Human mao b structure]]
[[Category: membrane]]
[[Category: Membrane]]
[[Category: mitochondrion]]
[[Category: Mitochondrion]]
[[Category: neuroprotection]]
[[Category: Neuroprotection]]
[[Category: oxidoreductase]]
[[Category: Oxidoreductase]]
[[Category: parkinson's disease]]
[[Category: Parkinson's disease]]
[[Category: reversible inhibitor binding]]
[[Category: Reversible inhibitor binding]]
[[Category: safinamide]]
[[Category: Safinamide]]
[[Category: transmembrane]]
[[Category: Transmembrane]]
 
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May  4 18:14:41 2008''
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Mar 31 05:08:47 2008''

Revision as of 15:14, 4 May 2008

File:2v61.gif

Template:STRUCTURE 2v61

STRUCTURE OF HUMAN MAO B IN COMPLEX WITH THE SELECTIVE INHIBITOR 7-(3-CHLOROBENZYLOXY)-4-(METHYLAMINO)METHYL-COUMARIN


Overview

Structures of human monoamine oxidase B (MAO B) in complex with safinamide and two coumarin derivatives, all sharing a common benzyloxy substituent, were determined by X-ray crystallography. These compounds competitively inhibit MAO B with Ki values in the 0.1-0.5 microM range that are 30-700-fold lower than those observed with MAO A. The inhibitors bind noncovalently to MAO B, occupying both the entrance and the substrate cavities and showing a similarly oriented benzyloxy substituent.

About this Structure

2V61 is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

Structures of human monoamine oxidase B complexes with selective noncovalent inhibitors: safinamide and coumarin analogs., Binda C, Wang J, Pisani L, Caccia C, Carotti A, Salvati P, Edmondson DE, Mattevi A, J Med Chem. 2007 Nov 15;50(23):5848-52. Epub 2007 Oct 4. PMID:17915852 Page seeded by OCA on Sun May 4 18:14:41 2008

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