2vb2: Difference between revisions

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[[Image:2vb2.jpg|left|200px]]
[[Image:2vb2.jpg|left|200px]]


{{Structure
<!--
|PDB= 2vb2 |SIZE=350|CAPTION= <scene name='initialview01'>2vb2</scene>, resolution 1.70&Aring;
The line below this paragraph, containing "STRUCTURE_2vb2", creates the "Structure Box" on the page.
|SITE= <scene name='pdbsite=AC1:So4+Binding+Site+For+Chain+X'>AC1</scene> and <scene name='pdbsite=AC2:Cu+Binding+Site+For+Chain+X'>AC2</scene>
You may change the PDB parameter (which sets the PDB file loaded into the applet)
|LIGAND= <scene name='pdbligand=CU:COPPER+(II)+ION'>CU</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>
or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
|ACTIVITY=
or leave the SCENE parameter empty for the default display.
|GENE=
-->
|DOMAIN=
{{STRUCTURE_2vb2|  PDB=2vb2 |  SCENE= }}  
|RELATEDENTRY=[[1zeq|1ZEQ]], [[2vb3|2VB3]]
|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2vb2 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2vb2 OCA], [http://www.ebi.ac.uk/pdbsum/2vb2 PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=2vb2 RCSB]</span>
}}


'''CRYSTAL STRUCTURE OF CU(I)CUSF'''
'''CRYSTAL STRUCTURE OF CU(I)CUSF'''
Line 34: Line 31:
[[Category: Stasser, J P.]]
[[Category: Stasser, J P.]]
[[Category: Xue, Y.]]
[[Category: Xue, Y.]]
[[Category: cation pi]]
[[Category: Cation pi]]
[[Category: copper]]
[[Category: Copper]]
[[Category: copper tolerance]]
[[Category: Copper tolerance]]
[[Category: copper transport]]
[[Category: Copper transport]]
[[Category: metal transport]]
[[Category: Metal transport]]
[[Category: metal-binding]]
[[Category: Metal-binding]]
[[Category: periplasm]]
[[Category: Periplasm]]
 
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May  4 18:31:33 2008''
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Mar 31 05:10:34 2008''

Revision as of 15:31, 4 May 2008

File:2vb2.jpg

Template:STRUCTURE 2vb2

CRYSTAL STRUCTURE OF CU(I)CUSF


Overview

Methionine-rich motifs have an important role in copper trafficking factors, including the CusF protein. Here we show that CusF uses a new metal recognition site wherein Cu(I) is tetragonally displaced from a Met2His ligand plane toward a conserved tryptophan. Spectroscopic studies demonstrate that both thioether ligation and strong cation-pi interactions with tryptophan stabilize metal binding. This novel active site chemistry affords mechanisms for control of adventitious metal redox and substitution chemistry.

About this Structure

2VB2 is a Single protein structure of sequence from Escherichia coli. Full crystallographic information is available from OCA.

Reference

Cu(I) recognition via cation-pi and methionine interactions in CusF., Xue Y, Davis AV, Balakrishnan G, Stasser JP, Staehlin BM, Focia P, Spiro TG, Penner-Hahn JE, O'Halloran TV, Nat Chem Biol. 2008 Feb;4(2):107-9. Epub 2007 Dec 23. PMID:18157124 Page seeded by OCA on Sun May 4 18:31:33 2008

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