6mxy: Difference between revisions

Line 1:

~~'''Unreleased structure'''~~

~~The entry~~ 6mxy is ~~ON HOLD~~ ~~until Paper Publication~~

==Structure of 53BP1 tandem Tudor domains in complex with small molecule UNC3351==

~~Authors~~:

== Structural highlights ==

<table><tr><td colspan='2'>[[6mxy]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6MXY OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6MXY FirstGlance]. <br>

~~Description~~:

</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=K6M:N-[3-(tert-butylamino)propyl]-3-(trifluoromethyl)benzamide'>K6M</scene>, <scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene></td></tr>

[[Category: ~~Unreleased Structures~~]]

<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6mxy FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6mxy OCA], [http://pdbe.org/6mxy PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6mxy RCSB], [http://www.ebi.ac.uk/pdbsum/6mxy PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6mxy ProSAT]</span></td></tr>

</table>

== Disease ==

[[http://www.uniprot.org/uniprot/TP53B_HUMAN TP53B_HUMAN]] Note=A chromosomal aberration involving TP53BP1 is found in a form of myeloproliferative disorder chronic with eosinophilia. Translocation t(5;15)(q33;q22) with PDGFRB creating a TP53BP1-PDGFRB fusion protein.

== Function ==

[[http://www.uniprot.org/uniprot/TP53B_HUMAN TP53B_HUMAN]] Plays a key role in the response to DNA damage. May have a role in checkpoint signaling during mitosis. Enhances TP53-mediated transcriptional activation.<ref>PMID:12364621</ref> <ref>PMID:17190600</ref>

== References ==

__TOC__

</StructureSection>

[[Category: Large Structures]]

[[Category: Botuyan, M V]]

[[Category: Cui, G]]

[[Category: Mer, G]]

[[Category: Dna damage response]]

[[Category: Protein binding]]

[[Category: Small molecule inhibitor]]

[[Category: Tudor domain]]

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@@ Line 1: / Line 1: @@
-'''Unreleased structure'''
-The entry 6mxy is ON HOLD  until Paper Publication
+==Structure of 53BP1 tandem Tudor domains in complex with small molecule UNC3351==
+<StructureSection load='6mxy' size='340' side='right'caption='[[6mxy]], [[Resolution|resolution]] 1.62&Aring;' scene=''>
-Authors:
+== Structural highlights ==
+<table><tr><td colspan='2'>[[6mxy]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6MXY OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6MXY FirstGlance]. <br>
-Description:
+</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=K6M:N-[3-(tert-butylamino)propyl]-3-(trifluoromethyl)benzamide'>K6M</scene>, <scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene></td></tr>
-[[Category: Unreleased Structures]]
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6mxy FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6mxy OCA], [http://pdbe.org/6mxy PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6mxy RCSB], [http://www.ebi.ac.uk/pdbsum/6mxy PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6mxy ProSAT]</span></td></tr>
+</table>
+== Disease ==
+[[http://www.uniprot.org/uniprot/TP53B_HUMAN TP53B_HUMAN]] Note=A chromosomal aberration involving TP53BP1 is found in a form of myeloproliferative disorder chronic with eosinophilia. Translocation t(5;15)(q33;q22) with PDGFRB creating a TP53BP1-PDGFRB fusion protein.
+== Function ==
+[[http://www.uniprot.org/uniprot/TP53B_HUMAN TP53B_HUMAN]] Plays a key role in the response to DNA damage. May have a role in checkpoint signaling during mitosis. Enhances TP53-mediated transcriptional activation.<ref>PMID:12364621</ref> <ref>PMID:17190600</ref>
+== References ==
+<references/>
+__TOC__
+</StructureSection>
+[[Category: Large Structures]]
+[[Category: Botuyan, M V]]
+[[Category: Cui, G]]
+[[Category: Mer, G]]
+[[Category: Dna damage response]]
+[[Category: Protein binding]]
+[[Category: Small molecule inhibitor]]
+[[Category: Tudor domain]]