6a6x: Difference between revisions
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The | ==The crystal structure of the Mtb MazE-MazF-mt9 complex== | ||
<StructureSection load='6a6x' size='340' side='right'caption='[[6a6x]], [[Resolution|resolution]] 2.70Å' scene=''> | |||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[6a6x]] is a 4 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6A6X OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6A6X FirstGlance]. <br> | |||
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr> | |||
[[Category: | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6a6x FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6a6x OCA], [http://pdbe.org/6a6x PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6a6x RCSB], [http://www.ebi.ac.uk/pdbsum/6a6x PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6a6x ProSAT]</span></td></tr> | ||
</table> | |||
== Function == | |||
[[http://www.uniprot.org/uniprot/MAZF7_MYCTU MAZF7_MYCTU]] Toxic component of a type II toxin-antitoxin (TA) module. Upon expression in E.coli and M.smegmatis inhibits cell growth and colony formation. Its toxic effect is neutralized by coexpression with cognate antitoxin MazE7 (PubMed:19016878, PubMed:20011113). Probably an endoribonuclease (By similarity).[UniProtKB:P9WIH9]<ref>PMID:19016878</ref> <ref>PMID:20011113</ref> [[http://www.uniprot.org/uniprot/MAZE7_MYCTU MAZE7_MYCTU]] Antitoxin component of a type II toxin-antitoxin (TA) system. Upon expression in E.coli but not in M.smegmatis neutralizes the effect of cognate toxin MazF7.<ref>PMID:19016878</ref> | |||
== References == | |||
<references/> | |||
__TOC__ | |||
</StructureSection> | |||
[[Category: Large Structures]] | |||
[[Category: Chen, R]] | |||
[[Category: Tu, J]] | |||
[[Category: Xie, W]] | [[Category: Xie, W]] | ||
[[Category: | [[Category: Mycobacterium tuberculosis]] | ||
[[Category: | [[Category: Toxin]] | ||
[[Category: Toxin-antitoxin system]] | |||
Revision as of 05:44, 3 July 2019
The crystal structure of the Mtb MazE-MazF-mt9 complex
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