6i5n: Difference between revisions

Line 1:

~~'''Unreleased structure'''~~

~~The entry~~ 6i5n is ~~ON HOLD~~

==Crystal structure of SOCS2:Elongin C:Elongin B in complex with growth hormone peptide==

~~Authors~~: ~~Kung~~, W.W., ~~Ramachandran~~, S., ~~Makukhin~~, N., ~~Ciulli, A~~.~~, Bruno, E~~.

== Structural highlights ==

<table><tr><td colspan='2'>[[6i5n]] is a 10 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6I5N OCA]. For a guided tour on the structure components use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6I5N FirstGlance].

~~Description~~: ~~Crystal structure~~ of SOCS2:~~Elongin~~ C:~~Elongin~~ B in complex ~~with growth hormone peptide~~

</td></tr><tr id='ligand'><td class="sblockLbl">[[Ligand|Ligands:]]</td><td class="sblockDat"><scene name='pdbligand=CO:COBALT+(II)+ION'>CO</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>

[[Category: ~~Unreleased~~ Structures]]

<tr id='NonStdRes'><td class="sblockLbl">[[Non-Standard_Residue|NonStd Res:]]</td><td class="sblockDat"><scene name='pdbligand=CAS:S-(DIMETHYLARSENIC)CYSTEINE'>CAS</scene>, <scene name='pdbligand=PTR:O-PHOSPHOTYROSINE'>PTR</scene>, <scene name='pdbligand=VLM:VALINYLAMINE'>VLM</scene></td></tr>

<tr id='resources'><td class="sblockLbl">Resources:</td><td class="sblockDat">[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6i5n FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6i5n OCA], [http://pdbe.org/6i5n PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6i5n RCSB], [http://www.ebi.ac.uk/pdbsum/6i5n PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6i5n ProSAT]</td></tr>

</table>

== Function ==

[[http://www.uniprot.org/uniprot/SOCS2_HUMAN SOCS2_HUMAN]] SOCS family proteins form part of a classical negative feedback system that regulates cytokine signal transduction. SOCS2 appears to be a negative regulator in the growth hormone/IGF1 signaling pathway. Probable substrate recognition component of a SCF-like ECS (Elongin BC-CUL2/5-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. [[http://www.uniprot.org/uniprot/ELOC_HUMAN ELOC_HUMAN]] SIII, also known as elongin, is a general transcription elongation factor that increases the RNA polymerase II transcription elongation past template-encoded arresting sites. Subunit A is transcriptionally active and its transcription activity is strongly enhanced by binding to the dimeric complex of the SIII regulatory subunits B and C (elongin BC complex).<ref>PMID:15590694</ref> The elongin BC complex seems to be involved as an adapter protein in the proteasomal degradation of target proteins via different E3 ubiquitin ligase complexes, including the von Hippel-Lindau ubiquitination complex CBC(VHL). By binding to BC-box motifs it seems to link target recruitment subunits, like VHL and members of the SOCS box family, to Cullin/RBX1 modules that activate E2 ubiquitination enzymes.<ref>PMID:15590694</ref> [[http://www.uniprot.org/uniprot/ELOB_HUMAN ELOB_HUMAN]] SIII, also known as elongin, is a general transcription elongation factor that increases the RNA polymerase II transcription elongation past template-encoded arresting sites. Subunit A is transcriptionally active and its transcription activity is strongly enhanced by binding to the dimeric complex of the SIII regulatory subunits B and C (elongin BC complex).<ref>PMID:7638163</ref> <ref>PMID:15590694</ref> The elongin BC complex seems to be involved as an adapter protein in the proteasomal degradation of target proteins via different E3 ubiquitin ligase complexes, including the von Hippel-Lindau ubiquitination complex CBC(VHL). By binding to BC-box motifs it seems to link target recruitment subunits, like VHL and members of the SOCS box family, to Cullin/RBX1 modules that activate E2 ubiquitination enzymes.<ref>PMID:7638163</ref> <ref>PMID:15590694</ref>

== References ==

__TOC__

</StructureSection>

[[Category: Large Structures]]

[[Category: Bruno, E]]

[[Category: Ciulli, A]]

[[Category: ~~Bruno~~, E]]

[[Category: Kung, W W]]

[[Category: Makukhin, N]]

[[Category: Ramachandran, S]]

[[Category: ~~Kung, W.W~~]]

[[Category: Complex]]

[[Category: ~~Makukhin, N~~]]

[[Category: Signaling protein]]

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-'''Unreleased structure'''
-The entry 6i5n is ON HOLD
+==Crystal structure of SOCS2:Elongin C:Elongin B in complex with growth hormone peptide==
+<StructureSection load='6i5n' size='340' side='right'caption='[[6i5n]], [[Resolution|resolution]] 1.98&Aring;' scene=''>
-Authors: Kung, W.W., Ramachandran, S., Makukhin, N., Ciulli, A., Bruno, E.
+== Structural highlights ==
+<table><tr><td colspan='2'>[[6i5n]] is a 10 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6I5N OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6I5N FirstGlance]. <br>
-Description: Crystal structure of SOCS2:Elongin C:Elongin B in complex with growth hormone peptide
+</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CO:COBALT+(II)+ION'>CO</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
-[[Category: Unreleased Structures]]
+<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=CAS:S-(DIMETHYLARSENIC)CYSTEINE'>CAS</scene>, <scene name='pdbligand=PTR:O-PHOSPHOTYROSINE'>PTR</scene>, <scene name='pdbligand=VLM:VALINYLAMINE'>VLM</scene></td></tr>
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6i5n FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6i5n OCA], [http://pdbe.org/6i5n PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6i5n RCSB], [http://www.ebi.ac.uk/pdbsum/6i5n PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6i5n ProSAT]</span></td></tr>
+</table>
+== Function ==
+[[http://www.uniprot.org/uniprot/SOCS2_HUMAN SOCS2_HUMAN]] SOCS family proteins form part of a classical negative feedback system that regulates cytokine signal transduction. SOCS2 appears to be a negative regulator in the growth hormone/IGF1 signaling pathway. Probable substrate recognition component of a SCF-like ECS (Elongin BC-CUL2/5-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. [[http://www.uniprot.org/uniprot/ELOC_HUMAN ELOC_HUMAN]] SIII, also known as elongin, is a general transcription elongation factor that increases the RNA polymerase II transcription elongation past template-encoded arresting sites. Subunit A is transcriptionally active and its transcription activity is strongly enhanced by binding to the dimeric complex of the SIII regulatory subunits B and C (elongin BC complex).<ref>PMID:15590694</ref>   The elongin BC complex seems to be involved as an adapter protein in the proteasomal degradation of target proteins via different E3 ubiquitin ligase complexes, including the von Hippel-Lindau ubiquitination complex CBC(VHL). By binding to BC-box motifs it seems to link target recruitment subunits, like VHL and members of the SOCS box family, to Cullin/RBX1 modules that activate E2 ubiquitination enzymes.<ref>PMID:15590694</ref>  [[http://www.uniprot.org/uniprot/ELOB_HUMAN ELOB_HUMAN]] SIII, also known as elongin, is a general transcription elongation factor that increases the RNA polymerase II transcription elongation past template-encoded arresting sites. Subunit A is transcriptionally active and its transcription activity is strongly enhanced by binding to the dimeric complex of the SIII regulatory subunits B and C (elongin BC complex).<ref>PMID:7638163</ref> <ref>PMID:15590694</ref>   The elongin BC complex seems to be involved as an adapter protein in the proteasomal degradation of target proteins via different E3 ubiquitin ligase complexes, including the von Hippel-Lindau ubiquitination complex CBC(VHL). By binding to BC-box motifs it seems to link target recruitment subunits, like VHL and members of the SOCS box family, to Cullin/RBX1 modules that activate E2 ubiquitination enzymes.<ref>PMID:7638163</ref> <ref>PMID:15590694</ref>
+== References ==
+<references/>
+__TOC__
+</StructureSection>
+[[Category: Large Structures]]
+[[Category: Bruno, E]]
 [[Category: Ciulli, A]]
-[[Category: Bruno, E]]
+[[Category: Kung, W W]]
+[[Category: Makukhin, N]]
 [[Category: Ramachandran, S]]
-[[Category: Kung, W.W]]
+[[Category: Complex]]
-[[Category: Makukhin, N]]
+[[Category: Signaling protein]]