6i80: Difference between revisions
From Proteopedia
Jump to navigationJump to search
m Protected "6i80" [edit=sysop:move=sysop] |
No edit summary |
||
| Line 1: | Line 1: | ||
==Crystal Structure of the second bromodomain of BRD2 in complex with RT53== | |||
<StructureSection load='6i80' size='340' side='right'caption='[[6i80]], [[Resolution|resolution]] 1.14Å' scene=''> | |||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[6i80]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6I80 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6I80 FirstGlance]. <br> | |||
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=H7B:2-[(4~{S})-6-(4-chlorophenyl)-8-methoxy-1-methyl-4~{H}-[1,2,4]triazolo[4,3-a][1,4]benzodiazepin-4-yl]-1-[4-(dimethylamino)piperidin-1-yl]ethanone'>H7B</scene></td></tr> | |||
[[Category: | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6i80 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6i80 OCA], [http://pdbe.org/6i80 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6i80 RCSB], [http://www.ebi.ac.uk/pdbsum/6i80 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6i80 ProSAT]</span></td></tr> | ||
[[Category: Arrowsmith, C | </table> | ||
[[Category: Bernardes, G | == Function == | ||
[[Category: | [[http://www.uniprot.org/uniprot/BRD2_HUMAN BRD2_HUMAN]] May play a role in spermatogenesis or folliculogenesis (By similarity). Binds hyperacetylated chromatin and plays a role in the regulation of transcription, probably by chromatin remodeling. Regulates transcription of the CCND1 gene. Plays a role in nucleosome assembly.<ref>PMID:18406326</ref> | ||
[[Category: | == References == | ||
<references/> | |||
__TOC__ | |||
</StructureSection> | |||
[[Category: Large Structures]] | |||
[[Category: Arrowsmith, C H]] | |||
[[Category: Bernardes, G J.L]] | |||
[[Category: Bountra, C]] | |||
[[Category: Edwards, A M]] | |||
[[Category: Filippakopoulos, P]] | [[Category: Filippakopoulos, P]] | ||
[[Category: Newman, J]] | [[Category: Newman, J]] | ||
[[Category: | [[Category: Picaud, S]] | ||
[[Category: Structural | [[Category: Structural genomic]] | ||
[[Category: | [[Category: Traquete, R]] | ||
[[Category: Bet]] | |||
[[Category: Bromodomain]] | |||
[[Category: Inhibitor]] | |||
[[Category: Rt53]] | |||
[[Category: Sgc]] | |||
[[Category: Transcription]] | |||
Revision as of 06:43, 27 November 2019
Crystal Structure of the second bromodomain of BRD2 in complex with RT53
| ||||||||||||
