6i81: Difference between revisions

Line 1:

~~'''Unreleased structure'''~~

~~The entry~~ 6i81 is ~~ON HOLD~~

==Crystal Structure of the second bromodomain of BRD2 in complex with RT56==

~~Authors~~: ~~Picaud~~, S., ~~Traquete~~, R., ~~Bernardes~~, G.J.L., ~~Newman~~, J., ~~Arrowsmith, C~~.H., ~~Edwards, A~~.M., ~~Bountra, C~~.~~, Filippakopoulos, P~~.~~, Structural Genomics Consortium (SGC)~~

== Structural highlights ==

<table><tr><td colspan='2'>[[6i81]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6I81 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6I81 FirstGlance]. <br>

~~Description~~: ~~Crystal Structure~~ of the ~~second bromodomain of BRD2~~ in ~~complex with RT56~~

</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=H7E:[1-[4-[2-[(4~{S})-6-(4-chlorophenyl)-8-methoxy-1-methyl-4~{H}-[1,2,4]triazolo[4,3-a][1,4]benzodiazepin-4-yl]ethanoylamino]phenyl]piperidin-4-yl]-trimethyl-azanium'>H7E</scene>, <scene name='pdbligand=MES:2-(N-MORPHOLINO)-ETHANESULFONIC+ACID'>MES</scene></td></tr>

[[Category: ~~Unreleased~~ Structures]]

<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6i81 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6i81 OCA], [http://pdbe.org/6i81 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6i81 RCSB], [http://www.ebi.ac.uk/pdbsum/6i81 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6i81 ProSAT]</span></td></tr>

[[Category: Arrowsmith, C.H]]

</table>

[[Category: Bernardes, G.J.L]]

== Function ==

[[Category: ~~Traquete~~, R]]

[[http://www.uniprot.org/uniprot/BRD2_HUMAN BRD2_HUMAN]] May play a role in spermatogenesis or folliculogenesis (By similarity). Binds hyperacetylated chromatin and plays a role in the regulation of transcription, probably by chromatin remodeling. Regulates transcription of the CCND1 gene. Plays a role in nucleosome assembly.<ref>PMID:18406326</ref>

[[Category: ~~Picaud~~, S]]

== References ==

__TOC__

</StructureSection>

[[Category: Large Structures]]

[[Category: Arrowsmith, C H]]

[[Category: Bernardes, G J.L]]

[[Category: Bountra, C]]

[[Category: Edwards, A M]]

[[Category: Filippakopoulos, P]]

[[Category: Newman, J]]

[[Category: ~~Edwards~~, ~~A.M~~]]

[[Category: Picaud, S]]

[[Category: Structural ~~Genomics Consortium (~~Sgc)]]

[[Category: Structural genomic]]

[[Category: ~~Bountra, C~~]]

[[Category: Traquete, R]]

[[Category: Bet]]

[[Category: Bromodomain]]

[[Category: Inhibitor]]

[[Category: Rt56]]

[[Category: Sgc]]

[[Category: Transcription]]

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@@ Line 1: / Line 1: @@
-'''Unreleased structure'''
-The entry 6i81 is ON HOLD
+==Crystal Structure of the second bromodomain of BRD2 in complex with RT56==
+<StructureSection load='6i81' size='340' side='right'caption='[[6i81]], [[Resolution|resolution]] 1.74&Aring;' scene=''>
-Authors: Picaud, S., Traquete, R., Bernardes, G.J.L., Newman, J., Arrowsmith, C.H., Edwards, A.M., Bountra, C., Filippakopoulos, P., Structural Genomics Consortium (SGC)
+== Structural highlights ==
+<table><tr><td colspan='2'>[[6i81]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6I81 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6I81 FirstGlance]. <br>
-Description: Crystal Structure of the second bromodomain of BRD2 in complex with RT56
+</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=H7E:[1-[4-[2-[(4~{S})-6-(4-chlorophenyl)-8-methoxy-1-methyl-4~{H}-[1,2,4]triazolo[4,3-a][1,4]benzodiazepin-4-yl]ethanoylamino]phenyl]piperidin-4-yl]-trimethyl-azanium'>H7E</scene>, <scene name='pdbligand=MES:2-(N-MORPHOLINO)-ETHANESULFONIC+ACID'>MES</scene></td></tr>
-[[Category: Unreleased Structures]]
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6i81 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6i81 OCA], [http://pdbe.org/6i81 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6i81 RCSB], [http://www.ebi.ac.uk/pdbsum/6i81 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6i81 ProSAT]</span></td></tr>
-[[Category: Arrowsmith, C.H]]
+</table>
-[[Category: Bernardes, G.J.L]]
+== Function ==
-[[Category: Traquete, R]]
+[[http://www.uniprot.org/uniprot/BRD2_HUMAN BRD2_HUMAN]] May play a role in spermatogenesis or folliculogenesis (By similarity). Binds hyperacetylated chromatin and plays a role in the regulation of transcription, probably by chromatin remodeling. Regulates transcription of the CCND1 gene. Plays a role in nucleosome assembly.<ref>PMID:18406326</ref>
-[[Category: Picaud, S]]
+== References ==
+<references/>
+__TOC__
+</StructureSection>
+[[Category: Large Structures]]
+[[Category: Arrowsmith, C H]]
+[[Category: Bernardes, G J.L]]
+[[Category: Bountra, C]]
+[[Category: Edwards, A M]]
 [[Category: Filippakopoulos, P]]
 [[Category: Newman, J]]
-[[Category: Edwards, A.M]]
+[[Category: Picaud, S]]
-[[Category: Structural Genomics Consortium (Sgc)]]
+[[Category: Structural genomic]]
-[[Category: Bountra, C]]
+[[Category: Traquete, R]]
+[[Category: Bet]]
+[[Category: Bromodomain]]
+[[Category: Inhibitor]]
+[[Category: Rt56]]
+[[Category: Sgc]]
+[[Category: Transcription]]