6ijf: Difference between revisions

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'''Unreleased structure'''


The entry 6ijf is ON HOLD  until Paper Publication
==Crystal structure of the type VI effector-immunity complex (Tae4-Tai4) from Agrobacterium tumefaciens==
<StructureSection load='6ijf' size='340' side='right' caption='[[6ijf]], [[Resolution|resolution]] 1.90&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[6ijf]] is a 4 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6IJF OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6IJF FirstGlance]. <br>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=1PE:PENTAETHYLENE+GLYCOL'>1PE</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6ijf FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6ijf OCA], [http://pdbe.org/6ijf PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6ijf RCSB], [http://www.ebi.ac.uk/pdbsum/6ijf PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6ijf ProSAT]</span></td></tr>
</table>
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
The type VI secretion system (T6SS) comprises needle-shaped multisubunit complexes that play a role in the microbial defense systems of Gram-negative bacteria. Some Gram-negative bacteria harboring a T6SS deliver toxic effector proteins into the cytoplasm or periplasm of competing bacteria in order to lyse and kill them. To avoid self-cell disruption, these bacteria have cognate immunity proteins that inhibit their toxic effector proteins. T6SS amidase effector protein 4 (Tae4) and T6SS amidase immunity protein 4 (Tai4) are a representative of the toxic effector-immunity pairs of the T6SS. Here, the three-dimensional structures of Tai4 and the Tae4-Tai4 complex from Agrobacterium tumefaciens are reported at 1.55 and 1.9 A resolution, respectively. A structural comparison with other Tae4-Tai4 homologs revealed similarities and differences in the catalytic and inhibitory mechanisms among the Tae4 and Tai4 family proteins.


Authors: Fukuhara, S., Nakane, T., Yamashita, K., Ishii, R., Ishitani, R., Nureki, O.
Crystal structure of the Agrobacterium tumefaciens type VI effector-immunity complex.,Fukuhara S, Nakane T, Yamashita K, Ishii R, Ishitani R, Nureki O Acta Crystallogr F Struct Biol Commun. 2018 Dec 1;74(Pt 12):810-816. doi:, 10.1107/S2053230X18016369. Epub 2018 Nov 30. PMID:30511676<ref>PMID:30511676</ref>


Description: Crystal structure of the type VI effector-immunity complex (Tae4-Tai4) from Agrobacterium tumefaciens
From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
[[Category: Unreleased Structures]]
</div>
[[Category: Nureki, O]]
<div class="pdbe-citations 6ijf" style="background-color:#fffaf0;"></div>
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Fukuhara, S]]
[[Category: Ishii, R]]
[[Category: Ishii, R]]
[[Category: Ishitani, R]]
[[Category: Ishitani, R]]
[[Category: Nakane, T]]
[[Category: Nakane, T]]
[[Category: Nureki, O]]
[[Category: Yamashita, K]]
[[Category: Yamashita, K]]
[[Category: Fukuhara, S]]
[[Category: Antitoxin]]
[[Category: Complex]]
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