6muj: Difference between revisions

Line 1:

~~'''Unreleased structure'''~~

~~The entry~~ 6muj is ~~ON HOLD~~ ~~until Paper Publication~~

==Formylglycine generating enzyme bound to copper==

~~Authors~~:

== Structural highlights ==

<table><tr><td colspan='2'>[[6muj]] is a 5 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6MUJ OCA]. For a guided tour on the structure components use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6MUJ FirstGlance].

~~Description~~:

</td></tr><tr id='ligand'><td class="sblockLbl">[[Ligand|Ligands:]]</td><td class="sblockDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=CU:COPPER+(II)+ION'>CU</scene>, <scene name='pdbligand=DTT:2,3-DIHYDROXY-1,4-DITHIOBUTANE'>DTT</scene>, <scene name='pdbligand=FMT:FORMIC+ACID'>FMT</scene>, <scene name='pdbligand=GLY:GLYCINE'>GLY</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=IMD:IMIDAZOLE'>IMD</scene></td></tr>

[[Category: ~~Unreleased Structures~~]]

<tr id='activity'><td class="sblockLbl">Activity:</td><td class="sblockDat">[http://en.wikipedia.org/wiki/Formylglycine-generating_enzyme Formylglycine-generating enzyme], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.8.3.7 1.8.3.7] </td></tr>

<tr id='resources'><td class="sblockLbl">Resources:</td><td class="sblockDat">[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6muj FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6muj OCA], [http://pdbe.org/6muj PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6muj RCSB], [http://www.ebi.ac.uk/pdbsum/6muj PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6muj ProSAT]</td></tr>

</table>

== Function ==

[[http://www.uniprot.org/uniprot/FGE_STRCO FGE_STRCO]] Oxidase that catalyzes the conversion of cysteine to 3-oxoalanine on target proteins. 3-oxoalanine modification, which is also named formylglycine (fGly), occurs in the maturation of arylsulfatases and some alkaline phosphatases that use the hydrated form of 3-oxoalanine as a catalytic nucleophile.<ref>PMID:18390551</ref> <ref>PMID:25931126</ref>

== References ==

__TOC__

</StructureSection>

[[Category: Formylglycine-generating enzyme]]

[[Category: Appel, M J]]

[[Category: Bertozzi, C]]

[[Category: Lafrance-Vanasse, J]]

[[Category: Tainer, J A]]

[[Category: Tsai, C L]]

[[Category: Copper oxidase]]

[[Category: Formylglycine]]

[[Category: Metal binding protein]]

[[Category: Metalloenzyme]]

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@@ Line 1: / Line 1: @@
-'''Unreleased structure'''
-The entry 6muj is ON HOLD  until Paper Publication
+==Formylglycine generating enzyme bound to copper==
+<StructureSection load='6muj' size='340' side='right' caption='[[6muj]], [[Resolution|resolution]] 2.25&Aring;' scene=''>
-Authors:
+== Structural highlights ==
+<table><tr><td colspan='2'>[[6muj]] is a 5 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6MUJ OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6MUJ FirstGlance]. <br>
-Description:
+</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=CU:COPPER+(II)+ION'>CU</scene>, <scene name='pdbligand=DTT:2,3-DIHYDROXY-1,4-DITHIOBUTANE'>DTT</scene>, <scene name='pdbligand=FMT:FORMIC+ACID'>FMT</scene>, <scene name='pdbligand=GLY:GLYCINE'>GLY</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=IMD:IMIDAZOLE'>IMD</scene></td></tr>
-[[Category: Unreleased Structures]]
+<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Formylglycine-generating_enzyme Formylglycine-generating enzyme], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.8.3.7 1.8.3.7] </span></td></tr>
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6muj FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6muj OCA], [http://pdbe.org/6muj PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6muj RCSB], [http://www.ebi.ac.uk/pdbsum/6muj PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6muj ProSAT]</span></td></tr>
+</table>
+== Function ==
+[[http://www.uniprot.org/uniprot/FGE_STRCO FGE_STRCO]] Oxidase that catalyzes the conversion of cysteine to 3-oxoalanine on target proteins. 3-oxoalanine modification, which is also named formylglycine (fGly), occurs in the maturation of arylsulfatases and some alkaline phosphatases that use the hydrated form of 3-oxoalanine as a catalytic nucleophile.<ref>PMID:18390551</ref> <ref>PMID:25931126</ref>
+== References ==
+<references/>
+__TOC__
+</StructureSection>
+[[Category: Formylglycine-generating enzyme]]
+[[Category: Appel, M J]]
+[[Category: Bertozzi, C]]
+[[Category: Lafrance-Vanasse, J]]
+[[Category: Tainer, J A]]
+[[Category: Tsai, C L]]
+[[Category: Copper oxidase]]
+[[Category: Formylglycine]]
+[[Category: Metal binding protein]]
+[[Category: Metalloenzyme]]