6mx0: Difference between revisions

Line 1:

~~'''Unreleased structure'''~~

~~The entry~~ 6mx0 is ~~ON HOLD until Paper Publication~~

==Crystal structure of human STING apoprotein (G230A, H232R, R293Q)==

~~Authors~~: ~~Lesburg~~, C.A., ~~Siu~~, T., Ho, T.

== Structural highlights ==

<table><tr><td colspan='2'>[[6mx0]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6MX0 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6MX0 FirstGlance]. <br>

~~Description~~: ~~Crystal structure~~ of ~~human STING apoprotein~~ (~~G230A~~, ~~H232R~~, ~~R293Q~~)

</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene></td></tr>

[[Category: ~~Unreleased Structures~~]]

<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6mx0 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6mx0 OCA], [http://pdbe.org/6mx0 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6mx0 RCSB], [http://www.ebi.ac.uk/pdbsum/6mx0 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6mx0 ProSAT]</span></td></tr>

</table>

== Function ==

[[http://www.uniprot.org/uniprot/STING_HUMAN STING_HUMAN]] Facilitator of innate immune signaling that acts as a sensor of cytosolic DNA from bacteria and viruses and promotes the production of type I interferon (IFN-alpha and IFN-beta). Innate immune response is triggered in response to non-CpG double-stranded DNA from viruses and bacteria delivered to the cytoplasm. Acts by recognizing and binding cyclic di-GMP (c-di-GMP), a second messenger produced by bacteria, and cyclic GMP-AMP (cGAMP), a messenger produced in response to DNA virus in the cytosol: upon binding of c-di-GMP or cGAMP, autoinhibition is alleviated and TMEM173/STING is able to activate both NF-kappa-B and IRF3 transcription pathways to induce expression of type I interferon and exert a potent anti-viral state. May be involved in translocon function, the translocon possibly being able to influence the induction of type I interferons. May be involved in transduction of apoptotic signals via its association with the major histocompatibility complex class II (MHC-II). Mediates death signaling via activation of the extracellular signal-regulated kinase (ERK) pathway.<ref>PMID:18818105</ref> <ref>PMID:18724357</ref> <ref>PMID:19776740</ref> <ref>PMID:19433799</ref> <ref>PMID:21074459</ref> <ref>PMID:21947006</ref> <ref>PMID:23258412</ref>

== References ==

__TOC__

</StructureSection>

[[Category: Ho, T]]

[[Category: Lesburg, C A]]

[[Category: Siu, T]]

[[Category: ~~Ho, T~~]]

[[Category: Immune system]]

[[Category: ~~Lesburg, C.A~~]]

[[Category: Innate immunity]]

[[Category: Open conformation]]

[[Category: Signaling]]

Navigation menu

Page actions

Page actions

Personal tools

Navigation

Search

Tools

@@ Line 1: / Line 1: @@
-'''Unreleased structure'''
-The entry 6mx0 is ON HOLD  until Paper Publication
+==Crystal structure of human STING apoprotein (G230A, H232R, R293Q)==
+<StructureSection load='6mx0' size='340' side='right' caption='[[6mx0]], [[Resolution|resolution]] 1.73&Aring;' scene=''>
-Authors: Lesburg, C.A., Siu, T., Ho, T.
+== Structural highlights ==
+<table><tr><td colspan='2'>[[6mx0]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6MX0 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6MX0 FirstGlance]. <br>
-Description: Crystal structure of human STING apoprotein (G230A, H232R, R293Q)
+</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene></td></tr>
-[[Category: Unreleased Structures]]
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6mx0 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6mx0 OCA], [http://pdbe.org/6mx0 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6mx0 RCSB], [http://www.ebi.ac.uk/pdbsum/6mx0 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6mx0 ProSAT]</span></td></tr>
+</table>
+== Function ==
+[[http://www.uniprot.org/uniprot/STING_HUMAN STING_HUMAN]] Facilitator of innate immune signaling that acts as a sensor of cytosolic DNA from bacteria and viruses and promotes the production of type I interferon (IFN-alpha and IFN-beta). Innate immune response is triggered in response to non-CpG double-stranded DNA from viruses and bacteria delivered to the cytoplasm. Acts by recognizing and binding cyclic di-GMP (c-di-GMP), a second messenger produced by bacteria, and cyclic GMP-AMP (cGAMP), a messenger produced in response to DNA virus in the cytosol: upon binding of c-di-GMP or cGAMP, autoinhibition is alleviated and TMEM173/STING is able to activate both NF-kappa-B and IRF3 transcription pathways to induce expression of type I interferon and exert a potent anti-viral state. May be involved in translocon function, the translocon possibly being able to influence the induction of type I interferons. May be involved in transduction of apoptotic signals via its association with the major histocompatibility complex class II (MHC-II). Mediates death signaling via activation of the extracellular signal-regulated kinase (ERK) pathway.<ref>PMID:18818105</ref> <ref>PMID:18724357</ref> <ref>PMID:19776740</ref> <ref>PMID:19433799</ref> <ref>PMID:21074459</ref> <ref>PMID:21947006</ref> <ref>PMID:23258412</ref>
+== References ==
+<references/>
+__TOC__
+</StructureSection>
+[[Category: Ho, T]]
+[[Category: Lesburg, C A]]
 [[Category: Siu, T]]
-[[Category: Ho, T]]
+[[Category: Immune system]]
-[[Category: Lesburg, C.A]]
+[[Category: Innate immunity]]
+[[Category: Open conformation]]
+[[Category: Signaling]]