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==Cereblon isoform 4 from Magnetospirillum gryphiswaldense in complex with 2-Thiohydantoin==
==Cereblon isoform 4 from Magnetospirillum gryphiswaldense in complex with 2-Thiohydantoin==
<StructureSection load='5oha' size='340' side='right' caption='[[5oha]], [[Resolution|resolution]] 1.55&Aring;' scene=''>
<StructureSection load='5oha' size='340' side='right'caption='[[5oha]], [[Resolution|resolution]] 1.55&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[5oha]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/Dsm_6361 Dsm 6361]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5OHA OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5OHA FirstGlance]. <br>
<table><tr><td colspan='2'>[[5oha]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Magnetospirillum_gryphiswaldense Magnetospirillum gryphiswaldense]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5OHA OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5OHA FirstGlance]. <br>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=9UW:2-sulfanylideneimidazol-4-one'>9UW</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.55&#8491;</td></tr>
<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">MGR_0879 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=55518 DSM 6361])</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=9UW:2-sulfanylideneimidazol-4-one'>9UW</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5oha FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5oha OCA], [http://pdbe.org/5oha PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5oha RCSB], [http://www.ebi.ac.uk/pdbsum/5oha PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5oha ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5oha FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5oha OCA], [https://pdbe.org/5oha PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5oha RCSB], [https://www.ebi.ac.uk/pdbsum/5oha PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5oha ProSAT]</span></td></tr>
</table>
</table>
== Function ==
[https://www.uniprot.org/uniprot/A4TVL0_9PROT A4TVL0_9PROT]
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
The protein cereblon serves as a substrate receptor of a ubiquitin ligase complex that can be tuned toward different target proteins by cereblon-binding agents. This approach to targeted protein degradation is exploited in different clinical settings and has sparked the development of a growing number of thalidomide derivatives. Here, we probe the chemical space of cereblon binding beyond such derivatives and work out a simple set of chemical requirements, delineating the metaclass of cereblon effectors. We report co-crystal structures for a diverse set of compounds, including commonly used pharmaceuticals, but also find that already minimalistic cereblon-binding moieties might exert teratogenic effects in zebrafish. Our results may guide the design of a post-thalidomide generation of therapeutic cereblon effectors and provide a framework for the circumvention of unintended cereblon binding by negative design for future pharmaceuticals.
Chemical Ligand Space of Cereblon.,Boichenko I, Bar K, Deiss S, Heim C, Albrecht R, Lupas AN, Hernandez Alvarez B, Hartmann MD ACS Omega. 2018 Sep 14;3(9):11163-11171. doi: 10.1021/acsomega.8b00959. , eCollection 2018 Sep 30. PMID:31459225<ref>PMID:31459225</ref>
From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
</div>
<div class="pdbe-citations 5oha" style="background-color:#fffaf0;"></div>
== References ==
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Dsm 6361]]
[[Category: Large Structures]]
[[Category: Albrecht, R]]
[[Category: Magnetospirillum gryphiswaldense]]
[[Category: Alvarez, B Hernandez]]
[[Category: Albrecht R]]
[[Category: Boichenko, I]]
[[Category: Boichenko I]]
[[Category: Hartmann, M D]]
[[Category: Hartmann MD]]
[[Category: Lupas, A N]]
[[Category: Hernandez Alvarez B]]
[[Category: Protein degradation]]
[[Category: Lupas AN]]
[[Category: Substrate recognition]]
[[Category: Teratogenicity]]
[[Category: Ubiquitin ligase]]
[[Category: Unknown function]]
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