2z6g: Difference between revisions
No edit summary |
No edit summary |
||
| Line 1: | Line 1: | ||
[[Image:2z6g.jpg|left|200px]] | [[Image:2z6g.jpg|left|200px]] | ||
<!-- | |||
The line below this paragraph, containing "STRUCTURE_2z6g", creates the "Structure Box" on the page. | |||
You may change the PDB parameter (which sets the PDB file loaded into the applet) | |||
or the SCENE parameter (which sets the initial scene displayed when the page is loaded), | |||
or leave the SCENE parameter empty for the default display. | |||
--> | |||
{{STRUCTURE_2z6g| PDB=2z6g | SCENE= }} | |||
| | |||
}} | |||
'''Crystal Structure of a Full-Length Zebrafish Beta-Catenin''' | '''Crystal Structure of a Full-Length Zebrafish Beta-Catenin''' | ||
| Line 31: | Line 28: | ||
[[Category: Xu, W.]] | [[Category: Xu, W.]] | ||
[[Category: Zheng, J.]] | [[Category: Zheng, J.]] | ||
[[Category: | [[Category: Beta-catenin]] | ||
[[Category: | [[Category: Cell adhesion]] | ||
[[Category: | [[Category: Crystal structure]] | ||
[[Category: | [[Category: Full-length]] | ||
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May 4 20:00:08 2008'' | |||
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on | |||
Revision as of 17:00, 4 May 2008
Crystal Structure of a Full-Length Zebrafish Beta-Catenin
Overview
beta-catenin plays essential roles in cell adhesion and Wnt signaling, while deregulation of beta-catenin is associated with multiple diseases including cancers. Here, we report the crystal structures of full-length zebrafish beta-catenin and a human beta-catenin fragment that contains both the armadillo repeat and the C-terminal domains. Our structures reveal that the N-terminal region of the C-terminal domain, a key component of the C-terminal transactivation domain, forms a long alpha helix that packs on the C-terminal end of the armadillo repeat domain, and thus forms part of the beta-catenin superhelical core. The existence of this helix redefines our view of interactions of beta-catenin with some of its critical partners, including ICAT and Chibby, which may form extensive interactions with this C-terminal domain alpha helix. Our crystallographic and NMR studies also suggest that the unstructured N-terminal and C-terminal tails interact with the ordered armadillo repeat domain in a dynamic and variable manner.
About this Structure
2Z6G is a Single protein structure of sequence from Danio rerio. Full crystallographic information is available from OCA.
Reference
Crystal Structure of a Full-Length beta-Catenin., Xing Y, Takemaru K, Liu J, Berndt JD, Zheng JJ, Moon RT, Xu W, Structure. 2008 Mar;16(3):478-87. PMID:18334222 Page seeded by OCA on Sun May 4 20:00:08 2008
