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| <StructureSection load='1stp' size='340' side='right' caption='Caption for this structure' scene=''> | | <StructureSection load='1stp' size='340' side='right' caption='Caption for this structure' scene=''> |
| This is a default text for your page '''Exophilin'''. Click above on '''edit this page''' to modify. Be careful with the < and > signs.
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| You may include any references to papers as in: the use of JSmol in Proteopedia <ref>DOI 10.1002/ijch.201300024</ref> or to the article describing Jmol <ref>PMID:21638687</ref> to the rescue.
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| == Function == | | == Function == |
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| '''Exophilin''' (EXP) are [[Synaptotagmin]]-like membrane proteins which bind Ca+2 and phospholipids are involved in synaptic vesicle docking. EXP-1 or '''rabphilin-3A''' | | '''Exophilin''' (EXP) are [[Synaptotagmin]]-like membrane proteins which bind Ca+2 and phospholipids are involved in synaptic vesicle docking. EXP-1 or '''rabphilin-3A''' is a rab3 effector at the synapse. Rab3A is a GTP-binding protein of synaptic vesicle that regulates vesicle exocytosis<ref>PMID:10407024</ref>. EXP-1 regulates synaptic vesicle traffic and does so at distinct stages of both the exocytotic and endocytotic pathways<ref>PMID:9450942</ref>. |
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| == Disease == | | == Disease == |
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| == Relevance == | | == Relevance == |
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| | EXP-1 is a diagnostically useful autoantigen for lymphocytic infundibulo-neurohypophysitis<ref>PMID:25919460</ref>. Reduction of EXP-1 immunoreactivity was found in patients of Alzheimer disease<ref>PMID:24200817</ref>. |
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| == Structural highlights == | | == Structural highlights == |
Revision as of 11:31, 4 December 2018
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Function
Exophilin (EXP) are Synaptotagmin-like membrane proteins which bind Ca+2 and phospholipids are involved in synaptic vesicle docking. EXP-1 or rabphilin-3A is a rab3 effector at the synapse. Rab3A is a GTP-binding protein of synaptic vesicle that regulates vesicle exocytosis[1]. EXP-1 regulates synaptic vesicle traffic and does so at distinct stages of both the exocytotic and endocytotic pathways[2].
Disease
Relevance
EXP-1 is a diagnostically useful autoantigen for lymphocytic infundibulo-neurohypophysitis[3]. Reduction of EXP-1 immunoreactivity was found in patients of Alzheimer disease[4].
Structural highlights
- ↑ Schluter OM, Schnell E, Verhage M, Tzonopoulos T, Nicoll RA, Janz R, Malenka RC, Geppert M, Sudhof TC. Rabphilin knock-out mice reveal that rabphilin is not required for rab3 function in regulating neurotransmitter release. J Neurosci. 1999 Jul 15;19(14):5834-46. PMID:10407024
- ↑ Burns ME, Sasaki T, Takai Y, Augustine GJ. Rabphilin-3A: a multifunctional regulator of synaptic vesicle traffic. J Gen Physiol. 1998 Feb;111(2):243-55. PMID:9450942
- ↑ Iwama S, Sugimura Y, Kiyota A, Kato T, Enomoto A, Suzuki H, Iwata N, Takeuchi S, Nakashima K, Takagi H, Izumida H, Ochiai H, Fujisawa H, Suga H, Arima H, Shimoyama Y, Takahashi M, Nishioka H, Ishikawa SE, Shimatsu A, Caturegli P, Oiso Y. Rabphilin-3A as a Targeted Autoantigen in Lymphocytic Infundibulo-neurohypophysitis. J Clin Endocrinol Metab. 2015 Jul;100(7):E946-54. doi: 10.1210/jc.2014-4209. Epub, 2015 Apr 28. PMID:25919460 doi:https://dx.doi.org/10.1210/jc.2014-4209
- ↑ Tan MG, Lee C, Lee JH, Francis PT, Williams RJ, Ramirez MJ, Chen CP, Wong PT, Lai MK. Decreased rabphilin 3A immunoreactivity in Alzheimer's disease is associated with Abeta burden. Neurochem Int. 2014 Jan;64:29-36. doi: 10.1016/j.neuint.2013.10.013. Epub 2013, Nov 5. PMID:24200817 doi:https://dx.doi.org/10.1016/j.neuint.2013.10.013
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3D structures of exophilin
Updated on 04-December-2018
{"openlevels":0}
- Exophilin-1 or rabphilin-3A
- Synaptotagmin, 4lt7 – rEXP C2A domain - rat
- 2cm6, 2cm5 – rEXP C2B domain
- 4np9, 4ns0 – rEXP C2A domain + inositol phosphate derivative
- 5lo8 – rEXP C2B domain + inositol phosphate derivative
- 5low, 5lob – rEXP C2B domain + SNAP25
- Exophilin-2 or synaptostagmin-like protein 4 or granuphilin
- Exophilin-3 or synaptostagmin-like protein 2A or melanophilin
- 2zet – mEXP SLP homology domain + RAB-27A - mouse
- 4kp3 – mEXP SLP globular tail domain + myosin-VA + RILPL2
- 4lx2 – mEXP SLP globular tail domain + myosin-VA
- Exophilin-4 or synaptostagmin-like protein 2
- 3bc1 – hEXP RAB-binding domain + RAB-27A
References
