Sandbox Reserved 1475: Difference between revisions
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<Structure load='1BI9' size='350' frame='true' align='right' caption='Retinal Dehydrogenase Type Two with NAD bound (PDB entry [[1bi9]])' scene=" /> | <Structure load='1BI9' size='350' frame='true' align='right' caption='Retinal Dehydrogenase Type Two with NAD bound (PDB entry [[1bi9]])' scene=" /> | ||
This molecular structure is Retinal Dehydrogenase Type Two (RalDH2). This enzyme is part of the super family Aldehyde Dehydrogenase. The function of this enzyme is to catalyze the oxidation of retinal to retinoic acid. Retinoic acid produces a putative morphogen that initiates pattern formation in the early embryo.<ref name="Lamb AL, Newcomber ME">PMID:10320326</ref> This is the last step in the formation of the hormone from Vitamin A (retinol). RalDH2 is expressed in ''Escherichia coli'' strain BL21(DE3) <ref name=Lamb Al, Wang X>PMID:9761861</ref> | This molecular structure is Retinal Dehydrogenase Type Two (RalDH2). This enzyme is part of the super family Aldehyde Dehydrogenase. The function of this enzyme is to catalyze the oxidation of retinal to retinoic acid. Retinoic acid produces a putative morphogen that initiates pattern formation in the early embryo.<ref name="Lamb AL, Newcomber ME">PMID:10320326</ref> This is the last step in the formation of the hormone from Vitamin A (retinol).<ref name="Lamb AL, Newcomber ME" /> Vitamin A that has been metabolized can produce retinoid derivatives which function in either vision or growth and development. <ref name ="Families of Retinoic Dehydrogenases" /> RalDH2 is expressed in ''Escherichia coli'' strain BL21(DE3) <ref name=Lamb Al, Wang X>PMID:9761861</ref> | ||
== Function == | == Function == | ||
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== Structural highlights == | == Structural highlights == | ||
==Substrate NAD== | |||
<Structure load='1bi9' size='350' frame='true' align='right' caption='RalDH2 with NAD bound molecule taken from (PDB entry [[1bi9]])' /> | |||
The crystal structure was cocrystallized with NAD, and was determined at a 2.7 Angstrom resolution. <ref name="Lamb AL, Newcomber ME" /> The structure was based on the mitochondrial aldehyde dehydrogenase type two. | |||
This is a sample scene created with SAT to <scene name="/12/3456/Sample/1">color</scene> by Group, and another to make <scene name="/12/3456/Sample/2">a transparent representation</scene> of the protein. You can make your own scenes on SAT starting from scratch or loading and editing one of these sample scenes. | This is a sample scene created with SAT to <scene name="/12/3456/Sample/1">color</scene> by Group, and another to make <scene name="/12/3456/Sample/2">a transparent representation</scene> of the protein. You can make your own scenes on SAT starting from scratch or loading and editing one of these sample scenes. | ||
