2z94: Difference between revisions
No edit summary |
No edit summary |
||
| Line 1: | Line 1: | ||
[[Image:2z94.jpg|left|200px]] | [[Image:2z94.jpg|left|200px]] | ||
<!-- | |||
The line below this paragraph, containing "STRUCTURE_2z94", creates the "Structure Box" on the page. | |||
You may change the PDB parameter (which sets the PDB file loaded into the applet) | |||
or the SCENE parameter (which sets the initial scene displayed when the page is loaded), | |||
| | or leave the SCENE parameter empty for the default display. | ||
| | --> | ||
{{STRUCTURE_2z94| PDB=2z94 | SCENE= }} | |||
}} | |||
'''Complex structure of SARS-CoV 3C-like protease with TDT''' | '''Complex structure of SARS-CoV 3C-like protease with TDT''' | ||
| Line 27: | Line 24: | ||
[[Category: Lee, C C.]] | [[Category: Lee, C C.]] | ||
[[Category: Wang, A H.]] | [[Category: Wang, A H.]] | ||
[[Category: | [[Category: Complex]] | ||
[[Category: | [[Category: Hydrolase]] | ||
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May 4 20:03:25 2008'' | |||
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on | |||
Revision as of 17:03, 4 May 2008
Complex structure of SARS-CoV 3C-like protease with TDT
Overview
Five active metal-conjugated inhibitors (PMA, TDT, EPDTC, JMF1586 and JMF1600) bound with the 3C-like protease of severe acute respiratory syndrome (SARS)-associated coronavirus were analyzed crystallographically. The complex structures reveal two major inhibition modes: Hg(2+)-PMA is coordinated to C(44), M(49) and Y(54) with a square planar geometry at the S3 pocket, whereas each Zn(2+) of the four zinc-inhibitors is tetrahedrally coordinated to the H(41)-C(145) catalytic dyad. For anti-SARS drug design, this Zn(2+)-centered coordination pattern would serve as a starting platform for inhibitor optimization.
About this Structure
2Z94 is a Single protein structure of sequence from Sars coronavirus. Full crystallographic information is available from OCA.
Reference
Structural basis of mercury- and zinc-conjugated complexes as SARS-CoV 3C-like protease inhibitors., Lee CC, Kuo CJ, Hsu MF, Liang PH, Fang JM, Shie JJ, Wang AH, FEBS Lett. 2007 Nov 27;581(28):5454-8. Epub 2007 Nov 5. PMID:17981158 Page seeded by OCA on Sun May 4 20:03:25 2008
