6n34: Difference between revisions

Line 1:

~~'''Unreleased structure'''~~

~~The entry~~ 6n34 is ~~ON HOLD~~ ~~until Paper Publication~~

==Crystal structure of the BTB domain of Human NS1-BP==

~~Authors~~:

== Structural highlights ==

<table><tr><td colspan='2'>[[6n34]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6N34 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6N34 FirstGlance]. <br>

~~Description~~:

</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6n34 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6n34 OCA], [http://pdbe.org/6n34 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6n34 RCSB], [http://www.ebi.ac.uk/pdbsum/6n34 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6n34 ProSAT]</span></td></tr>

[[Category: ~~Unreleased Structures~~]]

</table>

== Function ==

[[http://www.uniprot.org/uniprot/NS1BP_HUMAN NS1BP_HUMAN]] Plays a role in cell division and in the dynamic organization of the actin skeleton as a stabilizer of actin filaments by association with F-actin through Kelch repeats. Protects cells from cell death induced by actin destabilization; Protects neurons from dendritic spines and actin filaments damage induced by the actin-destabilizing cytochalasin B when overexpressed. Activates Erk signaling pathway when overexpressed in cultured cell lines (By similarity). May be a component of the cellular splicing machinery with a role in pre-mRNA splicing; may mediate the inhibition of splicing by NS/influenza virus NS1A protein. Functions as modifier of the AHR/Aryl hydrocarbon receptor pathway increasing the concentration of AHR available to activate transcription.<ref>PMID:16582008</ref>

== References ==

__TOC__

</StructureSection>

[[Category: Chook, Y M]]

[[Category: Fontoura, B]]

[[Category: Padavannil, A]]

[[Category: Shang, G]]

[[Category: Zhang, K]]

[[Category: Mrna export]]

[[Category: Splicing]]

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@@ Line 1: / Line 1: @@
-'''Unreleased structure'''
-The entry 6n34 is ON HOLD  until Paper Publication
+==Crystal structure of the BTB domain of Human NS1-BP==
+<StructureSection load='6n34' size='340' side='right' caption='[[6n34]], [[Resolution|resolution]] 2.80&Aring;' scene=''>
-Authors:
+== Structural highlights ==
+<table><tr><td colspan='2'>[[6n34]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6N34 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6N34 FirstGlance]. <br>
-Description:
+</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6n34 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6n34 OCA], [http://pdbe.org/6n34 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6n34 RCSB], [http://www.ebi.ac.uk/pdbsum/6n34 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6n34 ProSAT]</span></td></tr>
-[[Category: Unreleased Structures]]
+</table>
+== Function ==
+[[http://www.uniprot.org/uniprot/NS1BP_HUMAN NS1BP_HUMAN]] Plays a role in cell division and in the dynamic organization of the actin skeleton as a stabilizer of actin filaments by association with F-actin through Kelch repeats. Protects cells from cell death induced by actin destabilization; Protects neurons from dendritic spines and actin filaments damage induced by the actin-destabilizing cytochalasin B when overexpressed. Activates Erk signaling pathway when overexpressed in cultured cell lines (By similarity). May be a component of the cellular splicing machinery with a role in pre-mRNA splicing; may mediate the inhibition of splicing by NS/influenza virus NS1A protein. Functions as modifier of the AHR/Aryl hydrocarbon receptor pathway increasing the concentration of AHR available to activate transcription.<ref>PMID:16582008</ref>
+== References ==
+<references/>
+__TOC__
+</StructureSection>
+[[Category: Chook, Y M]]
+[[Category: Fontoura, B]]
+[[Category: Padavannil, A]]
+[[Category: Shang, G]]
+[[Category: Zhang, K]]
+[[Category: Mrna export]]
+[[Category: Splicing]]