Exophilin: Difference between revisions
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<StructureSection load='4np9' size='340' side='right' caption=' | <StructureSection load='4np9' size='340' side='right' caption='Rat rabphilin-3A C2A domain complex with inositol triphosphate and sulfate (PDB code [[4np9]])' scene=''> | ||
== Function == | == Function == | ||
'''Exophilin''' (EXP) are [[Synaptotagmin]]-like membrane proteins which bind Ca+2 and phospholipids are involved in synaptic vesicle docking. | '''Exophilin''' (EXP) are [[Synaptotagmin]]-like membrane proteins which bind Ca+2 ions and phospholipids are involved in synaptic vesicle docking. | ||
* EXP-1 or '''rabphilin-3A''' is a Rab3 effector at the synapse. Rab3A is a GTP-binding protein of synaptic vesicle that regulates vesicle exocytosis<ref>PMID:10407024</ref>. EXP-1 regulates synaptic vesicle traffic and does so at distinct stages of both the exocytotic and endocytotic pathways<ref>PMID:9450942</ref>.<br /> | * EXP-1 or '''rabphilin-3A''' is a Rab3 effector at the synapse. Rab3A is a GTP-binding protein of synaptic vesicle that regulates vesicle exocytosis<ref>PMID:10407024</ref>. EXP-1 regulates synaptic vesicle traffic and does so at distinct stages of both the exocytotic and endocytotic pathways<ref>PMID:9450942</ref>.<br /> | ||
* EXP-2 or '''granuphilin''' is a Rab27a effector. It is involved in tethering insulin granules to the plasma membrane in regulated exocytosis<ref>PMID:16216924</ref> by interacting with Rab27a and [[Syntaxin]]-1a<ref>PMID:15028737</ref>.<br /> | * EXP-2 or '''granuphilin''' is a Rab27a effector. It is involved in tethering insulin granules to the plasma membrane in regulated exocytosis<ref>PMID:16216924</ref> by interacting with Rab27a and [[Syntaxin]]-1a<ref>PMID:15028737</ref>.<br /> | ||
* EXP-3 or '''melanophilin''' links [[Myosin]] Va and the cargo vesicles in the cells through activation of ATPase producing the motor activity<ref>PMID:15760894</ref>.<br /> | * EXP-3 or '''melanophilin''' links [[Myosin]] Va and the cargo vesicles in the cells through activation of ATPase producing the motor activity<ref>PMID:15760894</ref>.<br /> | ||
== Relevance == | == Relevance == | ||
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== Structural highlights == | == Structural highlights == | ||
The C2A domain of rabphilin-3A binds the phosphate ions and phospholipid molecule in a groove in the calcium-binding polybasic region of the protein<ref>PMID:24302762</ref>. | |||
</StructureSection> | </StructureSection> | ||
