3g9v: Difference between revisions
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==Crystal structure of a soluble decoy receptor IL-22BP bound to interleukin-22== | ==Crystal structure of a soluble decoy receptor IL-22BP bound to interleukin-22== | ||
<StructureSection load='3g9v' size='340' side='right' caption='[[3g9v]], [[Resolution|resolution]] 2.76Å' scene=''> | <StructureSection load='3g9v' size='340' side='right'caption='[[3g9v]], [[Resolution|resolution]] 2.76Å' scene=''> | ||
== Structural highlights == | == Structural highlights == | ||
<table><tr><td colspan='2'>[[3g9v]] is a 4 chain structure with sequence from [ | <table><tr><td colspan='2'>[[3g9v]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3G9V OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3G9V FirstGlance]. <br> | ||
</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">IL22RA2 ([ | </td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">IL22RA2 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN]), IL22 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr> | ||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[ | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3g9v FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3g9v OCA], [https://pdbe.org/3g9v PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3g9v RCSB], [https://www.ebi.ac.uk/pdbsum/3g9v PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3g9v ProSAT]</span></td></tr> | ||
</table> | </table> | ||
== Function == | == Function == | ||
[[ | [[https://www.uniprot.org/uniprot/I22R2_HUMAN I22R2_HUMAN]] Isoform 2 is a receptor for IL22. Binds to IL22, prevents interaction with the functional IL-22R complex and blocks the activity of IL22 (in vitro). May play an important role as an IL22 antagonist in the regulation of inflammatory responses.<ref>PMID:11390454</ref> <ref>PMID:11390453</ref> <ref>PMID:11481447</ref> Isoform 1 may play a role in establishing and maintaining successful pregnancy.<ref>PMID:11390454</ref> <ref>PMID:11390453</ref> <ref>PMID:11481447</ref> [[https://www.uniprot.org/uniprot/IL22_HUMAN IL22_HUMAN]] Cytokine that contributes to the inflammatory response in vivo. | ||
== Evolutionary Conservation == | == Evolutionary Conservation == | ||
[[Image:Consurf_key_small.gif|200px|right]] | [[Image:Consurf_key_small.gif|200px|right]] | ||
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==See Also== | ==See Also== | ||
*[[Interleukin|Interleukin]] | *[[Interleukin 3D structures|Interleukin 3D structures]] | ||
*[[Interleukin receptor|Interleukin receptor]] | *[[Interleukin receptor 3D structures|Interleukin receptor 3D structures]] | ||
== References == | == References == | ||
<references/> | <references/> | ||
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</StructureSection> | </StructureSection> | ||
[[Category: Human]] | [[Category: Human]] | ||
[[Category: Large Structures]] | |||
[[Category: Bleicher, L]] | [[Category: Bleicher, L]] | ||
[[Category: Colau, D]] | [[Category: Colau, D]] | ||
