Sandbox Reserved 1472: Difference between revisions

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== Relevance (Disease) ==

Disease causes cellular stress in organisms and because heat shock proteins function to protect proteins from stressed conditions they have relevance in many pathological processes like cancer, neurodegenerative disease, infectious agents and more<ref name="hoter" />.Because Hsp90 works so flexibly to stabilize proteins it becomes a problem by helping oncogenic proteins function. However this is also a potential tool in fighting cancer by Hsp90 inhibition. Hsp90 has a high basal expression compared to most other heat shock proteins. If the organism is not under environmental stress Hsp90 may not be needed at high levels for homeostasis. However cancer cells are highly reliant on it. The largest interest in the recent study of Hsp90 is its use a cancer treatment.

Disease causes cellular stress in organisms and because heat shock proteins function to protect proteins from stressed conditions they have relevance in many pathological processes like cancer, neurodegenerative disease, infectious agents and more<ref name="hoter" />.Because Hsp90 works so flexibly to stabilize proteins it becomes a problem by helping oncogenic proteins function. However this is also a potential tool in fighting cancer by Hsp90 inhibition. Hsp90 has a high basal expression compared to most other heat shock proteins. If the organism is not under environmental stress Hsp90 may not be needed at high levels for homeostasis. However cancer cells are highly reliant on it. The largest interest in the recent study of Hsp90 is its use a cancer treatment.The two main natural inhibitors that can be used to inhibit Hsp90 are radicicol and geldanamycin. These inhibitors work by binding to Hsp90 where normally ATP would. These natural inhibitors have been studied in vitro and in vivo and have shown to affect cancer proliferation but they both have problems in regards to instability and toxicity<ref name="hoter" />.

== References ==

Sandbox Reserved 1472: Difference between revisions

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 == Relevance (Disease) ==
-Disease causes cellular stress in organisms and because heat shock proteins function to protect proteins from stressed conditions they have relevance in many pathological processes like cancer, neurodegenerative disease, infectious agents and more<ref name="hoter" />.Because  Hsp90 works so flexibly to stabilize proteins it becomes a problem by helping oncogenic proteins function. However this is also a potential tool in fighting cancer by Hsp90 inhibition. Hsp90 has a high basal expression compared to most other heat shock proteins. If the organism is not under environmental stress Hsp90 may not be needed at high levels for homeostasis. However cancer cells are highly reliant on it. The largest interest in the recent study of Hsp90 is its use a cancer treatment.
+Disease causes cellular stress in organisms and because heat shock proteins function to protect proteins from stressed conditions they have relevance in many pathological processes like cancer, neurodegenerative disease, infectious agents and more<ref name="hoter" />.Because  Hsp90 works so flexibly to stabilize proteins it becomes a problem by helping oncogenic proteins function. However this is also a potential tool in fighting cancer by Hsp90 inhibition. Hsp90 has a high basal expression compared to most other heat shock proteins. If the organism is not under environmental stress Hsp90 may not be needed at high levels for homeostasis. However cancer cells are highly reliant on it. The largest interest in the recent study of Hsp90 is its use a cancer treatment.The two main natural inhibitors that can be used to inhibit Hsp90 are radicicol and geldanamycin. These inhibitors work by binding to Hsp90 where normally ATP would. These natural inhibitors have been studied in vitro and in vivo and have shown to affect cancer proliferation but they both have problems in regards to instability and toxicity<ref name="hoter" />.
 == References ==
 <references/>