Exophilin

spinqualitylabelsall models Rat rabphilin-3A C2A domain complex with inositol triphosphate and sulfate (PDB code 4np9) Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image   Print3D Function Exophilin (EXP) are Synaptotagmin-like membrane proteins which bind Ca+2 ions and phospholipids are involved in synaptic vesicle docking. EXP-1 or rabphilin-3A is a Rab3 effector at the synapse. Rab3A is a GTP-binding protein of synaptic vesicle that regulates vesicle exocytosis. EXP-1 regulates synaptic vesicle traffic and does so at distinct stages of both the exocytotic and endocytotic pathways. EXP-2 or granuphilin is a Rab27a effector. It is involved in tethering insulin granules to the plasma membrane in regulated exocytosis by interacting with Rab27a and Syntaxin-1a. EXP-3 or melanophilin links Myosin Va and the cargo vesicles in the cells through activation of ATPase producing the motor activity. Relevance EXP-1 is a diagnostically useful autoantigen for lymphocytic infundibulo-neurohypophysitis. Reduction of EXP-1 immunoreactivity was found in patients of Alzheimer disease. EXP-4 or synaptotagmin-like protein 2 is associated with the metastatic potential of ovarian carcinoma. Structural highlights The C2A domain of rabphilin-3A binds the phospholipid molecule and the phosphate ions and in a groove in the calcium-binding polybasic region of the protein. The rabphilin-3A residues interactiong with inositol triphosphate are colored according to their charge (Anionic (-) / Cationic (+)). Water molecules are shown as red spheres.

3D structures of exophilin

Updated on 09-December-2018

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• Exophilin-1 or rabphilin-3A
  • Synaptotagmin, Syntaxin – rEXP C2A domain - rat
    
  • Myosin, 2cm5 – rEXP C2B domain
    
  • 4np9, 4ns0 – rEXP C2A domain + inositol phosphate derivative
    
  • 5lo8 – rEXP C2B domain + inositol phosphate derivative
    
  • 5low, 5lob – rEXP C2B domain + SNAP25
    
• Exophilin-2 or synaptostagmin-like protein 4 or granuphilin
  • 2csz, 5x6t – hEXP RING domain - NMR
    
  • 3fdw – hEXP C2 domain
    
• Exophilin-3 or synaptotagmin-like protein 2A or melanophilin
  • 2zet – mEXP SLP homology domain + RAB-27A - mouse
    
  • 4kp3 – mEXP SLP globular tail domain + myosin-VA + RILPL2
    
  • 4lx2 – mEXP SLP globular tail domain + myosin-VA
    
• Exophilin-4 or synaptotagmin-like protein 2
  • 3bc1 – hEXP Rab-binding domain + Rab27A
    

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Michal Harel, Alexander Berchansky