6ibs: Difference between revisions
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==Crystal structure of NDM-1 beta-lactamase in complex with boronic inhibitor cpd 6== | |||
<StructureSection load='6ibs' size='340' side='right'caption='[[6ibs]], [[Resolution|resolution]] 1.37Å' scene=''> | |||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[6ibs]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6IBS OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6IBS FirstGlance]. <br> | |||
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=HB8:[7-[(2-methylpropan-2-yl)oxycarbonylamino]-1-benzothiophen-2-yl]-tris(oxidanyl)boranuide'>HB8</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr> | |||
[[Category: | <tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Beta-lactamase Beta-lactamase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.5.2.6 3.5.2.6] </span></td></tr> | ||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6ibs FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6ibs OCA], [http://pdbe.org/6ibs PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6ibs RCSB], [http://www.ebi.ac.uk/pdbsum/6ibs PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6ibs ProSAT]</span></td></tr> | |||
</table> | |||
== Function == | |||
[[http://www.uniprot.org/uniprot/BLAN1_KLEPN BLAN1_KLEPN]] Confers resistance to many beta-lactam antibiotics, including some carbapenems. Does not confer resistance to the polymixin colistin or the fluoroquinolone ciprofloxacin. | |||
__TOC__ | |||
</StructureSection> | |||
[[Category: Beta-lactamase]] | |||
[[Category: Large Structures]] | |||
[[Category: Bellio, P]] | |||
[[Category: Celenza, G]] | |||
[[Category: Cendron, L]] | |||
[[Category: Costi, M P]] | |||
[[Category: Maso, L]] | |||
[[Category: Montanari, M]] | |||
[[Category: Quotadamo, A]] | |||
[[Category: Tondi, D]] | |||
[[Category: Venturelli, A]] | |||
[[Category: Acyclic boronic inhibitor]] | |||
[[Category: Bacterial resistance]] | |||
[[Category: Hydrolase]] | |||
