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==Crystal Structure of the oligomerization domain of VP35 from Reston virus, mercury derivative==
==Crystal Structure of the oligomerization domain of VP35 from Reston virus, mercury derivative==
<StructureSection load='6gbr' size='340' side='right' caption='[[6gbr]], [[Resolution|resolution]] 3.15&Aring;' scene=''>
<StructureSection load='6gbr' size='340' side='right'caption='[[6gbr]], [[Resolution|resolution]] 3.15&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[6gbr]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Ebola_virus_reston Ebola virus reston]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6GBR OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6GBR FirstGlance]. <br>
<table><tr><td colspan='2'>[[6gbr]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Reston_ebolavirus Reston ebolavirus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6GBR OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6GBR FirstGlance]. <br>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=MBO:MERCURIBENZOIC+ACID'>MBO</scene></td></tr>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 3.15&#8491;</td></tr>
<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">VP35, REBOVgp2 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=186539 Ebola virus Reston])</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=MBO:MERCURIBENZOIC+ACID'>MBO</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6gbr FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6gbr OCA], [http://pdbe.org/6gbr PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6gbr RCSB], [http://www.ebi.ac.uk/pdbsum/6gbr PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6gbr ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6gbr FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6gbr OCA], [https://pdbe.org/6gbr PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6gbr RCSB], [https://www.ebi.ac.uk/pdbsum/6gbr PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6gbr ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
[[http://www.uniprot.org/uniprot/VP35_EBORR VP35_EBORR]] Acts as a polymerase cofactor in the RNA polymerase transcription and replication complex. Prevents establishment of cellular antiviral state by blocking virus-induced phosphorylation and activation of interferon regulatory factor 3 (IRF3), a transcription factor critical for the induction of interferons alpha and beta. The mechanism by which this blockage occurs remains incompletely defined, a hypothesis suggests that VP35 dsRNA-binding activity prevents activation of IRF3 by sequestering dsRNA. Also inhibits the antiviral effect mediated by the interferon-induced, double-stranded RNA-activated protein kinase EIF2AK2/PKR (By similarity).  
[https://www.uniprot.org/uniprot/VP35_EBORR VP35_EBORR] Acts as a polymerase cofactor in the RNA polymerase transcription and replication complex. Prevents establishment of cellular antiviral state by blocking virus-induced phosphorylation and activation of interferon regulatory factor 3 (IRF3), a transcription factor critical for the induction of interferons alpha and beta. The mechanism by which this blockage occurs remains incompletely defined, a hypothesis suggests that VP35 dsRNA-binding activity prevents activation of IRF3 by sequestering dsRNA. Also inhibits the antiviral effect mediated by the interferon-induced, double-stranded RNA-activated protein kinase EIF2AK2/PKR (By similarity).
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Ebola virus reston]]
[[Category: Large Structures]]
[[Category: Baumeister, W]]
[[Category: Reston ebolavirus]]
[[Category: Bracher, A]]
[[Category: Baumeister W]]
[[Category: Nagy, I]]
[[Category: Bracher A]]
[[Category: Orsini, M]]
[[Category: Nagy I]]
[[Category: Weyher-Stingl, E]]
[[Category: Orsini M]]
[[Category: Zinzula, L]]
[[Category: Weyher-Stingl E]]
[[Category: Coiled-coil]]
[[Category: Zinzula L]]
[[Category: Viral protein]]
Retrieved from "https://proteopedia.org/6gbr"