Sandbox Reserved 1482: Difference between revisions
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'''1984''': Factor VIII was first characterized by scientists at Genentech | '''1984''': Factor VIII was first characterized by scientists at Genentech | ||
== Function == | == Function == | ||
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Alpha-D-mannose, calcium ion (Ca2+), copper ion (Cu2+) and N-acetl-D-glucosamine are the four ligands the factor VIII is able to bind. | Alpha-D-mannose, calcium ion (Ca2+), copper ion (Cu2+) and N-acetl-D-glucosamine are the four ligands the factor VIII is able to bind. | ||
In factor VIII there are two copper ions and their binding sites are internally within the A1 and the A3 domain, but also a single calcium ion, whose binding site was located in the A1 domain. | In factor VIII there are two copper ions and their binding sites are internally within the A1 and the A3 domain, but also a single calcium ion, whose binding site was located in the A1 domain. | ||
== Disease == | == Disease == | ||
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The major treatment of the bleeding disorder associated with haemophilia A is the infusion of factor VIII, which leads to the correction of hemostasis. | The major treatment of the bleeding disorder associated with haemophilia A is the infusion of factor VIII, which leads to the correction of hemostasis. | ||
== Relevance == | == Relevance == | ||
