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==Diazabicyclooctenone ETX2514 bound to Class D beta lactamase OXA-24 from A. baumannii==
==Diazabicyclooctenone ETX2514 bound to Class D beta lactamase OXA-24 from A. baumannii==
<StructureSection load='5vfd' size='340' side='right' caption='[[5vfd]], [[Resolution|resolution]] 1.93&Aring;' scene=''>
<StructureSection load='5vfd' size='340' side='right'caption='[[5vfd]], [[Resolution|resolution]] 1.93&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[5vfd]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Aciba Aciba]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5VFD OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5VFD FirstGlance]. <br>
<table><tr><td colspan='2'>[[5vfd]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Acinetobacter_baumannii Acinetobacter baumannii]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5VFD OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5VFD FirstGlance]. <br>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=9CM:(2S,5R)-4-methyl-7-oxo-6-(sulfooxy)-1,6-diazabicyclo[3.2.1]oct-3-ene-2-carboxamide'>9CM</scene>, <scene name='pdbligand=9CP:(2S,5R)-1-formyl-4-methyl-5-[(sulfooxy)amino]-1,2,5,6-tetrahydropyridine-2-carboxamide'>9CP</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.93&#8491;</td></tr>
<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=KCX:LYSINE+NZ-CARBOXYLIC+ACID'>KCX</scene></td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=9CM:(2S,5R)-4-methyl-7-oxo-6-(sulfooxy)-1,6-diazabicyclo[3.2.1]oct-3-ene-2-carboxamide'>9CM</scene>, <scene name='pdbligand=9CP:(2S,5R)-1-formyl-4-methyl-5-[(sulfooxy)amino]-1,2,5,6-tetrahydropyridine-2-carboxamide'>9CP</scene>, <scene name='pdbligand=KCX:LYSINE+NZ-CARBOXYLIC+ACID'>KCX</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">blaOXA-33, bla-OXA-40, blaOXA-24, blaOXA-40, oxa-24, oxa40, A8G88_08245 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=470 ACIBA])</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5vfd FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5vfd OCA], [https://pdbe.org/5vfd PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5vfd RCSB], [https://www.ebi.ac.uk/pdbsum/5vfd PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5vfd ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5vfd FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5vfd OCA], [http://pdbe.org/5vfd PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5vfd RCSB], [http://www.ebi.ac.uk/pdbsum/5vfd PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5vfd ProSAT]</span></td></tr>
</table>
</table>
== Function ==
[https://www.uniprot.org/uniprot/Q8RLA6_ACIBA Q8RLA6_ACIBA]
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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==See Also==
==See Also==
*[[Beta-lactamase|Beta-lactamase]]
*[[Beta-lactamase 3D structures|Beta-lactamase 3D structures]]
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Aciba]]
[[Category: Acinetobacter baumannii]]
[[Category: Lahiri, S]]
[[Category: Large Structures]]
[[Category: Olivier, N B]]
[[Category: Lahiri S]]
[[Category: A. baumannii]]
[[Category: Olivier NB]]
[[Category: Astrazeneca]]
[[Category: Beta-lactamase]]
[[Category: Covalent inhibitor]]
[[Category: Entasis]]
[[Category: Etx2514]]
[[Category: Hydrolase-hydrolase inhibitor complex]]
[[Category: Pbp gram negative]]
Retrieved from "https://proteopedia.org/5vfd"