6neo: Difference between revisions

Line 1:

~~'''Unreleased structure'''~~

~~The entry~~ 6neo is ~~ON HOLD~~

==Crystal structure of PprA filament from Deinococcus radiodurans==

~~Authors~~: ~~Szabla~~, R., ~~Junop~~, M.S., ~~Rok~~, M.

== Structural highlights ==

<table><tr><td colspan='2'>[[6neo]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6NEO OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6NEO FirstGlance]. <br>

~~Description~~: ~~Crystal structure~~ of PprA ~~filament from Deinococcus radiodurans~~

</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6neo FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6neo OCA], [http://pdbe.org/6neo PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6neo RCSB], [http://www.ebi.ac.uk/pdbsum/6neo PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6neo ProSAT]</span></td></tr>

[[Category: ~~Unreleased Structures~~]]

</table>

== Function ==

[[http://www.uniprot.org/uniprot/PPRA_DEIRA PPRA_DEIRA]] dsDNA-binding protein that contributes to the ionizing radiation resistance of D.radiodurans. Plays a role in DNA repair and genome reconstitution, and is necessary for recovery from severe genomic fragmentation as a result of exposure to severe levels of ionizing radiation. In vitro, binds to double-stranded DNA carrying strand breaks and stimulates the DNA end-joining reaction catalyzed by DNA ligases. Thus, PprA plays a critical role in a non-homologous end-joining (NHEJ) pathway for the repair of radiation-induced DNA double-strands breaks. Cannot bind to dsDNA without strand breaks or single-stranded DNA.<ref>PMID:15454524</ref> <ref>PMID:15458422</ref>

== References ==

__TOC__

</StructureSection>

[[Category: Junop, M S]]

[[Category: Rok, M]]

~~[[Category: Junop, M.S]]~~

[[Category: Szabla, R]]

[[Category: Dna binding protein]]

[[Category: Dna damage repair]]

[[Category: Filament formation]]

[[Category: Genome segregation]]

[[Category: Protein fibril]]

[[Category: Radiation induced]]

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@@ Line 1: / Line 1: @@
-'''Unreleased structure'''
-The entry 6neo is ON HOLD
+==Crystal structure of PprA filament from Deinococcus radiodurans==
+<StructureSection load='6neo' size='340' side='right' caption='[[6neo]], [[Resolution|resolution]] 5.94&Aring;' scene=''>
-Authors: Szabla, R., Junop, M.S., Rok, M.
+== Structural highlights ==
+<table><tr><td colspan='2'>[[6neo]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6NEO OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6NEO FirstGlance]. <br>
-Description: Crystal structure of PprA filament from Deinococcus radiodurans
+</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6neo FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6neo OCA], [http://pdbe.org/6neo PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6neo RCSB], [http://www.ebi.ac.uk/pdbsum/6neo PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6neo ProSAT]</span></td></tr>
-[[Category: Unreleased Structures]]
+</table>
+== Function ==
+[[http://www.uniprot.org/uniprot/PPRA_DEIRA PPRA_DEIRA]] dsDNA-binding protein that contributes to the ionizing radiation resistance of D.radiodurans. Plays a role in DNA repair and genome reconstitution, and is necessary for recovery from severe genomic fragmentation as a result of exposure to severe levels of ionizing radiation. In vitro, binds to double-stranded DNA carrying strand breaks and stimulates the DNA end-joining reaction catalyzed by DNA ligases. Thus, PprA plays a critical role in a non-homologous end-joining (NHEJ) pathway for the repair of radiation-induced DNA double-strands breaks. Cannot bind to dsDNA without strand breaks or single-stranded DNA.<ref>PMID:15454524</ref> <ref>PMID:15458422</ref>
+== References ==
+<references/>
+__TOC__
+</StructureSection>
+[[Category: Junop, M S]]
 [[Category: Rok, M]]
-[[Category: Junop, M.S]]
 [[Category: Szabla, R]]
+[[Category: Dna binding protein]]
+[[Category: Dna damage repair]]
+[[Category: Filament formation]]
+[[Category: Genome segregation]]
+[[Category: Protein fibril]]
+[[Category: Radiation induced]]