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'''Unreleased structure'''


The entry 6nft is ON HOLD
==Structure of USP5 zinc-finger ubiquitin binding domain co-crystallized with (4-oxoquinazolin-3(4H)-yl)acetic acid==
 
<StructureSection load='6nft' size='340' side='right' caption='[[6nft]], [[Resolution|resolution]] 1.65&Aring;' scene=''>
Authors: Harding, R.J., Mann, M.K., Tempel, W., Bountra, C., Arrowmsmith, C.M., Edwards, A.M., Schapira, M.
== Structural highlights ==
 
<table><tr><td colspan='2'>[[6nft]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6NFT OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6NFT FirstGlance]. <br>
Description: Structure of USP5 zinc-finger ubiquitin binding domain co-crystallized with C(C([O-])=O)N1C=Nc2ccccc2C1=O
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=KKG:(4-oxoquinazolin-3(4H)-yl)acetic+acid'>KKG</scene>, <scene name='pdbligand=UNX:UNKNOWN+ATOM+OR+ION'>UNX</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
[[Category: Unreleased Structures]]
<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[6dxt|6dxt]], [[6dxh|6dxh]]</td></tr>
<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Ubiquitinyl_hydrolase_1 Ubiquitinyl hydrolase 1], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.19.12 3.4.19.12] </span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6nft FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6nft OCA], [http://pdbe.org/6nft PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6nft RCSB], [http://www.ebi.ac.uk/pdbsum/6nft PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6nft ProSAT]</span></td></tr>
</table>
== Function ==
[[http://www.uniprot.org/uniprot/UBP5_HUMAN UBP5_HUMAN]] Cleaves linear and branched multiubiquitin polymers with a marked preference for branched polymers. Involved in unanchored 'Lys-48'-linked polyubiquitin disassembly. Binds linear and 'Lys-63'-linked polyubiquitin with a lower affinity. Knock-down of USP5 causes the accumulation of p53/TP53 and an increase in p53/TP53 transcriptional activity because the unanchored polyubiquitin that accumulates is able to compete with ubiquitinated p53/TP53 but not with MDM2 for proteasomal recognition.<ref>PMID:19098288</ref> 
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Ubiquitinyl hydrolase 1]]
[[Category: Arrowmsmith, C M]]
[[Category: Bountra, C]]
[[Category: Edwards, A M]]
[[Category: Harding, R J]]
[[Category: Mann, M K]]
[[Category: Structural genomic]]
[[Category: Schapira, M]]
[[Category: Schapira, M]]
[[Category: Edwards, A.M]]
[[Category: Mann, M.K]]
[[Category: Harding, R.J]]
[[Category: Arrowmsmith, C.M]]
[[Category: Bountra, C]]
[[Category: Tempel, W]]
[[Category: Tempel, W]]
[[Category: Hydrolase]]
[[Category: Sgc]]
[[Category: Usp5]]
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