6q91: Difference between revisions

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'''Unreleased structure'''


The entry 6q91 is ON HOLD
==Structure of human galactokinase 1 bound with 5-Chloro-N-isobutyl-2-methoxybenzamide==
<StructureSection load='6q91' size='340' side='right'caption='[[6q91]], [[Resolution|resolution]] 2.40&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[6q91]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6Q91 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6Q91 FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.4&#8491;</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GAL:BETA-D-GALACTOSE'>GAL</scene>, <scene name='pdbligand=HFK:2-(1,3-benzoxazol-2-ylamino)spiro[1,6,7,8-tetrahydroquinazoline-4,1-cyclohexane]-5-one'>HFK</scene>, <scene name='pdbligand=HR8:5-chloranyl-2-methoxy-~{N}-(2-methylpropyl)benzamide'>HR8</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6q91 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6q91 OCA], [https://pdbe.org/6q91 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6q91 RCSB], [https://www.ebi.ac.uk/pdbsum/6q91 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6q91 ProSAT]</span></td></tr>
</table>
== Disease ==
[https://www.uniprot.org/uniprot/GALK1_HUMAN GALK1_HUMAN] Defects in GALK1 are the cause of galactosemia II (GALCT2) [MIM:[https://omim.org/entry/230200 230200]. Galactosemia II is an autosomal recessive deficiency characterized by congenital cataracts during infancy and presenile cataracts in the adult population. The cataracts are secondary to accumulation of galactitol in the lenses.<ref>PMID:10521295</ref> <ref>PMID:10790206</ref> <ref>PMID:11231902</ref> <ref>PMID:11139256</ref> <ref>PMID:12694189</ref> <ref>PMID:15024738</ref>
== Function ==
[https://www.uniprot.org/uniprot/GALK1_HUMAN GALK1_HUMAN] Major enzyme for galactose metabolism.


Authors: Mackinnon, S.R., Bezerra, G.A., Zhang, M., Foster, W., Krojer, T., Brandao-Neto, J., Douangamath, A., Arrowsmith, C., Edwards, A., Bountra, C., Brennan, P., Lai, K., Yue, W.W.
==See Also==
 
*[[Galactokinase|Galactokinase]]
Description: Structure of human galactokinase 1 bound with 5-Chloro-N-isobutyl-2-methoxybenzamide
== References ==
[[Category: Unreleased Structures]]
<references/>
[[Category: Foster, W]]
__TOC__
[[Category: Brandao-Neto, J]]
</StructureSection>
[[Category: Lai, K]]
[[Category: Homo sapiens]]
[[Category: Bezerra, G.A]]
[[Category: Large Structures]]
[[Category: Yue, W.W]]
[[Category: Arrowsmith C]]
[[Category: Arrowsmith, C]]
[[Category: Bezerra GA]]
[[Category: Zhang, M]]
[[Category: Bountra C]]
[[Category: Edwards, A]]
[[Category: Brandao-Neto J]]
[[Category: Douangamath, A]]
[[Category: Brennan P]]
[[Category: Mackinnon, S.R]]
[[Category: Douangamath A]]
[[Category: Krojer, T]]
[[Category: Edwards A]]
[[Category: Brennan, P]]
[[Category: Foster W]]
[[Category: Bountra, C]]
[[Category: Krojer T]]
[[Category: Lai K]]
[[Category: Mackinnon SR]]
[[Category: Yue WW]]
[[Category: Zhang M]]
Retrieved from "https://proteopedia.org/6q91"