6qb6: Difference between revisions
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==Mcl1 in complex with a Fab== | |||
<StructureSection load='6qb6' size='340' side='right'caption='[[6qb6]], [[Resolution|resolution]] 2.24Å' scene=''> | |||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[6qb6]] is a 3 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6QB6 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6QB6 FirstGlance]. <br> | |||
</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[6qb3|6qb3]], [[6qb4|6qb4]], [[6fs0|6fs0]]</td></tr> | |||
[[Category: | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6qb6 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6qb6 OCA], [http://pdbe.org/6qb6 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6qb6 RCSB], [http://www.ebi.ac.uk/pdbsum/6qb6 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6qb6 ProSAT]</span></td></tr> | ||
</table> | |||
== Function == | |||
[[http://www.uniprot.org/uniprot/MCL1_HUMAN MCL1_HUMAN]] Involved in the regulation of apoptosis versus cell survival, and in the maintenance of viability but not of proliferation. Mediates its effects by interactions with a number of other regulators of apoptosis. Isoform 1 inhibits apoptosis. Isoform 2 promotes apoptosis.<ref>PMID:10766760</ref> | |||
== References == | |||
<references/> | |||
__TOC__ | |||
</StructureSection> | |||
[[Category: Large Structures]] | |||
[[Category: Hargreaves, D]] | [[Category: Hargreaves, D]] | ||
[[Category: Apoptosis]] | |||
[[Category: Azd5991]] | |||
[[Category: Fab]] | |||
[[Category: Mcl1]] | |||
