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==MCL1 in complex with an indole acid ligand==
==MCL1 in complex with an indole acid ligand==
<StructureSection load='6fs1' size='340' side='right' caption='[[6fs1]], [[Resolution|resolution]] 1.60&Aring;' scene=''>
<StructureSection load='6fs1' size='340' side='right'caption='[[6fs1]], [[Resolution|resolution]] 1.60&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[6fs1]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6FS1 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6FS1 FirstGlance]. <br>
<table><tr><td colspan='2'>[[6fs1]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6FS1 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6FS1 FirstGlance]. <br>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=E4Q:7-[3-[(1,5-dimethylpyrazol-3-yl)methylsulfanylmethyl]-1,5-dimethyl-pyrazol-4-yl]-3-(3-naphthalen-1-yloxypropyl)-1~{H}-indole-2-carboxylic+acid'>E4Q</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene></td></tr>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.6&#8491;</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6fs1 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6fs1 OCA], [http://pdbe.org/6fs1 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6fs1 RCSB], [http://www.ebi.ac.uk/pdbsum/6fs1 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6fs1 ProSAT]</span></td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=E4Q:7-[3-[(1,5-dimethylpyrazol-3-yl)methylsulfanylmethyl]-1,5-dimethyl-pyrazol-4-yl]-3-(3-naphthalen-1-yloxypropyl)-1~{H}-indole-2-carboxylic+acid'>E4Q</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6fs1 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6fs1 OCA], [https://pdbe.org/6fs1 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6fs1 RCSB], [https://www.ebi.ac.uk/pdbsum/6fs1 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6fs1 ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
[[http://www.uniprot.org/uniprot/MCL1_HUMAN MCL1_HUMAN]] Involved in the regulation of apoptosis versus cell survival, and in the maintenance of viability but not of proliferation. Mediates its effects by interactions with a number of other regulators of apoptosis. Isoform 1 inhibits apoptosis. Isoform 2 promotes apoptosis.<ref>PMID:10766760</ref>
[https://www.uniprot.org/uniprot/MCL1_HUMAN MCL1_HUMAN] Involved in the regulation of apoptosis versus cell survival, and in the maintenance of viability but not of proliferation. Mediates its effects by interactions with a number of other regulators of apoptosis. Isoform 1 inhibits apoptosis. Isoform 2 promotes apoptosis.<ref>PMID:10766760</ref>  
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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</div>
</div>
<div class="pdbe-citations 6fs1" style="background-color:#fffaf0;"></div>
<div class="pdbe-citations 6fs1" style="background-color:#fffaf0;"></div>
==See Also==
*[[B-cell lymphoma proteins 3D structures|B-cell lymphoma proteins 3D structures]]
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Hargreaves, D]]
[[Category: Homo sapiens]]
[[Category: Kasmirski, S]]
[[Category: Large Structures]]
[[Category: Immune system]]
[[Category: Hargreaves D]]
[[Category: Indole acid]]
[[Category: Kasmirski S]]
[[Category: Mcl1]]
Retrieved from "https://proteopedia.org/6fs1"