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==TRANSCRIPTIONAL REPRESSOR ETHR FROM MYCOBACTERIUM TUBERCULOSIS IN COMPLEX WITH BDM44850==
==TRANSCRIPTIONAL REPRESSOR ETHR FROM MYCOBACTERIUM TUBERCULOSIS IN COMPLEX WITH BDM44850==
<StructureSection load='6hoe' size='340' side='right' caption='[[6hoe]], [[Resolution|resolution]] 1.90&Aring;' scene=''>
<StructureSection load='6hoe' size='340' side='right'caption='[[6hoe]], [[Resolution|resolution]] 1.90&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[6hoe]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6HOE OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6HOE FirstGlance]. <br>
<table><tr><td colspan='2'>[[6hoe]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Mycobacterium_tuberculosis_CDC1551 Mycobacterium tuberculosis CDC1551]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6HOE OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6HOE FirstGlance]. <br>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GH2:ethyl+2-[4-[4-[3,3,3-tris(fluoranyl)propylcarbamoyl]phenyl]-1,3-thiazol-2-yl]ethanoate'>GH2</scene></td></tr>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.9&#8491;</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6hoe FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6hoe OCA], [http://pdbe.org/6hoe PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6hoe RCSB], [http://www.ebi.ac.uk/pdbsum/6hoe PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6hoe ProSAT]</span></td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GH2:ethyl+2-[4-[4-[3,3,3-tris(fluoranyl)propylcarbamoyl]phenyl]-1,3-thiazol-2-yl]ethanoate'>GH2</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6hoe FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6hoe OCA], [https://pdbe.org/6hoe PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6hoe RCSB], [https://www.ebi.ac.uk/pdbsum/6hoe PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6hoe ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
[[http://www.uniprot.org/uniprot/ETHR_MYCTO ETHR_MYCTO]] Involved in the repression of the monooxygenase EthA which is responsible of the formation of the active metabolite of ethionamide (ETH).  
[https://www.uniprot.org/uniprot/ETHR_MYCTU ETHR_MYCTU] Involved in the repression of the monooxygenase EthA which is responsible of the formation of the active metabolite of ethionamide (ETH).<ref>PMID:10869356</ref> <ref>PMID:10944230</ref>
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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</div>
</div>
<div class="pdbe-citations 6hoe" style="background-color:#fffaf0;"></div>
<div class="pdbe-citations 6hoe" style="background-color:#fffaf0;"></div>
==See Also==
*[[Tetracycline repressor protein 3D structures|Tetracycline repressor protein 3D structures]]
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Wintjens, R]]
[[Category: Large Structures]]
[[Category: Wohlkonig, A]]
[[Category: Mycobacterium tuberculosis CDC1551]]
[[Category: Complex]]
[[Category: Wintjens R]]
[[Category: Dna binding protein]]
[[Category: Wohlkonig A]]
[[Category: Drug design]]
[[Category: Ethionamide]]
[[Category: Helix-turn-helix]]
[[Category: Inhibitor]]
[[Category: Tetr-family]]
[[Category: Tuberculosis]]
Retrieved from "https://proteopedia.org/6hoe"