3k6l: Difference between revisions
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==The structure of E.coli peptide deformylase (PDF) in complex with peptidomimetic ligand BB2827== | ==The structure of E.coli peptide deformylase (PDF) in complex with peptidomimetic ligand BB2827== | ||
<StructureSection load='3k6l' size='340' side='right' caption='[[3k6l]], [[Resolution|resolution]] 2.15Å' scene=''> | <StructureSection load='3k6l' size='340' side='right'caption='[[3k6l]], [[Resolution|resolution]] 2.15Å' scene=''> | ||
== Structural highlights == | == Structural highlights == | ||
<table><tr><td colspan='2'>[[3k6l]] is a 3 chain structure with sequence from [ | <table><tr><td colspan='2'>[[3k6l]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Escherichia_coli_K-12 Escherichia coli K-12]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3K6L OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3K6L FirstGlance]. <br> | ||
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=2BB:(2S,3R)-N~4~-[(1S)-1-(DIMETHYLCARBAMOYL)-2,2-DIMETHYLPROPYL]-N~1~,2-DIHYDROXY-3-(2-METHYLPROPYL)BUTANEDIAMIDE'>2BB</scene>, <scene name='pdbligand=NI:NICKEL+(II)+ION'>NI</scene | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.15Å</td></tr> | ||
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=2BB:(2S,3R)-N~4~-[(1S)-1-(DIMETHYLCARBAMOYL)-2,2-DIMETHYLPROPYL]-N~1~,2-DIHYDROXY-3-(2-METHYLPROPYL)BUTANEDIAMIDE'>2BB</scene>, <scene name='pdbligand=NI:NICKEL+(II)+ION'>NI</scene></td></tr> | |||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3k6l FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3k6l OCA], [https://pdbe.org/3k6l PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3k6l RCSB], [https://www.ebi.ac.uk/pdbsum/3k6l PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3k6l ProSAT]</span></td></tr> | |||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[ | |||
</table> | </table> | ||
== Function == | == Function == | ||
[ | [https://www.uniprot.org/uniprot/DEF_ECOLI DEF_ECOLI] Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions.[HAMAP-Rule:MF_00163] | ||
== Evolutionary Conservation == | == Evolutionary Conservation == | ||
[[Image:Consurf_key_small.gif|200px|right]] | [[Image:Consurf_key_small.gif|200px|right]] | ||
| Line 23: | Line 22: | ||
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
[[Category: | [[Category: Escherichia coli K-12]] | ||
[[Category: | [[Category: Large Structures]] | ||
[[Category: Barker | [[Category: Barker J]] | ||
[[Category: Cheng | [[Category: Cheng RKY]] | ||
[[Category: Crawley | [[Category: Crawley L]] | ||
[[Category: Felicetti | [[Category: Felicetti B]] | ||
[[Category: Whittaker | [[Category: Whittaker M]] | ||
[[Category: Wood | [[Category: Wood M]] | ||
Latest revision as of 08:10, 6 September 2023
The structure of E.coli peptide deformylase (PDF) in complex with peptidomimetic ligand BB2827
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