High affinity nerve growth factor receptor

spinqualitylabelsall models Caption for this structure Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image   Print3D Function High affinity nerve growth factor receptor (TrkA) is a tyrosine kinase receptor. TrkA ligand - nerve growth factor activates the receptor by stabilizing homodimer formation which initiates transautophosphorylation. Relevance TrkA has a role in the pathogenesis of psoriasis and its inhibitors are studied in the development of novel therapeutics for the disease.

3D structures of high affinity nerve growth factor receptor

Updated on 26-December-2018

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• High affinity nerve growth factor receptor; Domains – nerve growth factor-binding 36-383; transmembrane 410-447; catalytic+juxtamembrane 376-698; kinase 498-796
  • 1he7 – hTrkA residues 282-413 – human
    
  • 2n90 – hTrkA transmembrane domain – NMR
    
  • 4crp – hTrkA nerve growth factor-binding domain (mutant) – NMR
    
  • 4f0i, 4gt5 – hTrkA kinase domain
    
• High affinity nerve growth factor receptor complex
  • 5kvt, 5wr7 – hTrkA kinase domain + anticancer drug
    
  • 4aoj, 4pmm, 4pmp, 4pms, 4pmt, 4yne, 4yps, 5h3q, 6dkb, 6dkg, 6dki, 6dkw – hTrkAChoE kinase domain + inhibitor
    
  • 5kmj, 5kmk, 5kml, 5kmm, 5kmn, 5kmo, 6d1y, 6d1z, 6d20, 5i8a, 5jfs, 5jfv, 5jfw, 5jfx, 5kmi, – hTrkAChoE catalytic+juxtamembrane domains 376-698 + inhibitor
    
  • 2ifg – hTrkAChoE nerve growth factor-binding domain + nerve growth factor
    

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