2c6d: Difference between revisions
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==Overview== | ==Overview== | ||
A novel series of 5-aminopyrimidinyl quinazolines has been developed from, anilino-quinazoline 1, which was identified in a high throughput screen, for Aurora A. Introduction of the pyrimidine ring and optimisation of the, substituents both on this ring and at the C7 position of the quinazoline, led to the discovery of compounds that are highly specific Aurora kinase, inhibitors. Co-crystallisation of one of these inhibitors with a fragment, of Aurora A shows the importance of the benzamido group in achieving, selectivity. | A novel series of 5-aminopyrimidinyl quinazolines has been developed from, anilino-quinazoline 1, which was identified in a high throughput screen, for Aurora A. Introduction of the pyrimidine ring and optimisation of the, substituents both on this ring and at the C7 position of the quinazoline, led to the discovery of compounds that are highly specific Aurora kinase, inhibitors. Co-crystallisation of one of these inhibitors with a fragment, of Aurora A shows the importance of the benzamido group in achieving, selectivity. | ||
==Disease== | |||
Known diseases associated with this structure: Colon cancer, susceptibility to OMIM:[[http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=603072 603072]] | |||
==About this Structure== | ==About this Structure== | ||
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[[Category: transferase]] | [[Category: transferase]] | ||
''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on Mon Nov | ''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on Mon Nov 12 21:11:34 2007'' | ||
