Domain: Difference between revisions
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A protein ''domain'' usually means a sequence of amino acids that folds, independently of the remainder of the full-length sequence, into a compact stable structure. Water-soluble domains typically have hydrophobic cores. Some small full-length proteins consist of a single domain, but most proteins have two or more domains. A domain is typically 100-250 amino acids in length<ref name="EPR" />, but can sometimes be shorter or longer. | A protein ''domain'' usually means a sequence of amino acids that folds, independently of the remainder of the full-length sequence, into a compact stable structure. Water-soluble domains typically have hydrophobic cores. Some small full-length proteins consist of a single domain, but most proteins have two or more domains. A domain is typically 100-250 amino acids in length<ref name="EPR" />, but can sometimes be shorter or longer. | ||
In 2006, chains with a single domain in the CATH database had an average length of 159<ref name="cath2006">PMID: 17135200</ref>. | |||
Examples: | Examples: | ||
