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==Crystal Structure of the 25kDa Subunit of Human Cleavage factor Im in complex with RNA UGUAAA==
==Crystal Structure of the 25kDa Subunit of Human Cleavage factor Im in complex with RNA UGUAAA==
<StructureSection load='3mdi' size='340' side='right' caption='[[3mdi]], [[Resolution|resolution]] 2.07&Aring;' scene=''>
<StructureSection load='3mdi' size='340' side='right'caption='[[3mdi]], [[Resolution|resolution]] 2.07&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[3mdi]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3MDI OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3MDI FirstGlance]. <br>
<table><tr><td colspan='2'>[[3mdi]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3MDI OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3MDI FirstGlance]. <br>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene></td></tr>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.07&#8491;</td></tr>
<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[3mdg|3mdg]], [[2cl3|2cl3]], [[2j8q|2j8q]], [[3bap|3bap]], [[3bho|3bho]]</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene></td></tr>
<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">CFIM25, CPSF25, CPSF5, NUDT21 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3mdi FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3mdi OCA], [https://pdbe.org/3mdi PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3mdi RCSB], [https://www.ebi.ac.uk/pdbsum/3mdi PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3mdi ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3mdi FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3mdi OCA], [http://pdbe.org/3mdi PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3mdi RCSB], [http://www.ebi.ac.uk/pdbsum/3mdi PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=3mdi ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
[[http://www.uniprot.org/uniprot/CPSF5_HUMAN CPSF5_HUMAN]] Component of the cleavage factor Im (CFIm) complex that plays a key role in pre-mRNA 3'-processing. Involved in association with CPSF6 or CPSF7 in pre-MRNA 3'-end poly(A) site cleavage and poly(A) addition. NUDT21/CPSF5 binds to cleavage and polyadenylation RNA substrates. The homodimer mediates simultaneous sequence-specific recognition of two 5'-UGUA-3' elements within the pre-mRNA. Binds to, but does not hydrolyze mono- and di-adenosine nucleotides. May have a role in mRNA export.<ref>PMID:9659921</ref> <ref>PMID:8626397</ref> <ref>PMID:14690600</ref> <ref>PMID:20695905</ref> <ref>PMID:20479262</ref> <ref>PMID:21295486</ref>
[https://www.uniprot.org/uniprot/CPSF5_HUMAN CPSF5_HUMAN] Component of the cleavage factor Im (CFIm) complex that plays a key role in pre-mRNA 3'-processing. Involved in association with CPSF6 or CPSF7 in pre-MRNA 3'-end poly(A) site cleavage and poly(A) addition. NUDT21/CPSF5 binds to cleavage and polyadenylation RNA substrates. The homodimer mediates simultaneous sequence-specific recognition of two 5'-UGUA-3' elements within the pre-mRNA. Binds to, but does not hydrolyze mono- and di-adenosine nucleotides. May have a role in mRNA export.<ref>PMID:9659921</ref> <ref>PMID:8626397</ref> <ref>PMID:14690600</ref> <ref>PMID:20695905</ref> <ref>PMID:20479262</ref> <ref>PMID:21295486</ref>  
== Evolutionary Conservation ==
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
[[Image:Consurf_key_small.gif|200px|right]]
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Human]]
[[Category: Homo sapiens]]
[[Category: Doublie, S]]
[[Category: Large Structures]]
[[Category: Gilmartin, G M]]
[[Category: Doublie S]]
[[Category: Yang, Q]]
[[Category: Gilmartin GM]]
[[Category: Cf im]]
[[Category: Yang Q]]
[[Category: Cleavage factor]]
[[Category: Cpsf5]]
[[Category: Mrna processing]]
[[Category: Nudix protein]]
[[Category: Protein-rna complex]]
[[Category: Rna binding protein]]
[[Category: Rna binding-rna complex]]
Retrieved from "https://proteopedia.org/3mdi"