Sandbox Reserved 1491: Difference between revisions

Line 9:

KDM4C plays a main role in the modification of cell cycle genes expression and thus involved in the growth of tumoral cells.

~~This is a default text for your page ''''''. Click above on '''edit this page''' to modify. Be careful with the < and > signs.~~

~~You may include any references to papers as in: the use of JSmol in Proteopedia <ref>DOI 10.1002/ijch.201300024</ref> or to the article describing Jmol <ref>PMID:21638687</ref> to the rescue.~~

== Function ==

Line 18:

Line 17:

Two families of histone-lysine demethylases (KDM) have been identified as follows : the flavin (FAD) -dependent lysine-specific demethylases and the Fe(II)-dependent Jumonji C (JmjC) family. JmjC[1] is subfamily of histone demethylases which regroups several proteins containing a specific catalytic domain called Jmjc found in 2xml structure. KDM4 demethylases belong to the JmjC family and contains six members : KDM4A-F.

[[Image:Reactionjpg.jpg | thumb]]

[[Image:Reactionjpg.jpg | thumb | upright=3,5 | Enzymatic reaction of demethylation of H3K9(me3) and H3K36(me3) by KDM4C ]]

KDM4C/JMJD2 is a protein which converts specific trimethylated histone residues to the dimethylated form. Indeed, it catalyzes the demethylation of both histone H3 Lysine 9 (H3K9me3) and Lysine 36 (H3K36me3) by hydroxylation of the lysine methyl group leading to a dissociation of the methyl group from the lysine histone tail. KDM4C employs 2-oxoglutarate (OG), Fe2+ and oxygen as cosubstrates to promote its enzymatic reaction, thus the dissociation of methyl groups. ~~[[Image:Reactionjpg.jpg | thumb]]~~

KDM4C/JMJD2 is a protein which converts specific trimethylated histone residues to the dimethylated form. Indeed, it catalyzes the demethylation of both histone H3 Lysine 9 (H3K9me3) and Lysine 36 (H3K36me3) by hydroxylation of the lysine methyl group leading to a dissociation of the methyl group from the lysine histone tail. KDM4C employs 2-oxoglutarate (OG), Fe2+ and oxygen as cosubstrates to promote its enzymatic reaction, thus the dissociation of methyl groups.

== Structural highlights ==

Sandbox Reserved 1491: Difference between revisions

Navigation menu

Page actions

Page actions

Personal tools

Navigation

Search

Tools

@@ Line 9: / Line 9: @@
 KDM4C plays a main role in the modification of cell cycle genes expression and thus involved in the growth of tumoral cells.
 <StructureSection load='2xml' size='340' side='right' caption='Structure of 2xml - monomeric domain of KDM4C' scene=''>
-This is a default text for your page ''''''. Click above on '''edit this page''' to modify. Be careful with the &lt; and &gt; signs.
-You may include any references to papers as in: the use of JSmol in Proteopedia <ref>DOI 10.1002/ijch.201300024</ref> or to the article describing Jmol <ref>PMID:21638687</ref> to the rescue.
 == Function ==
@@ Line 18: / Line 17: @@
 Two families of histone-lysine demethylases (KDM) have been identified as follows : the flavin (FAD) -dependent lysine-specific demethylases and the Fe(II)-dependent Jumonji C (JmjC) family. JmjC[1] is subfamily of histone demethylases which regroups several proteins containing a specific catalytic domain called Jmjc found in 2xml structure. KDM4 demethylases belong to the JmjC family and contains six members : KDM4A-F.
-[[Image:Reactionjpg.jpg | thumb]]
+[[Image:Reactionjpg.jpg | thumb | upright=3,5 | Enzymatic reaction of demethylation of H3K9(me3) and H3K36(me3) by KDM4C ]]
-KDM4C/JMJD2 is a protein which converts specific trimethylated histone residues to the dimethylated form. Indeed, it catalyzes the demethylation of both histone H3 Lysine 9 (H3K9me3) and Lysine 36 (H3K36me3) by hydroxylation of the lysine methyl group leading to a dissociation of the methyl group from the lysine histone tail. KDM4C employs 2-oxoglutarate (OG), Fe2+ and oxygen as cosubstrates to promote its enzymatic reaction, thus the dissociation of methyl groups. [[Image:Reactionjpg.jpg | thumb]]
+KDM4C/JMJD2 is a protein which converts specific trimethylated histone residues to the dimethylated form. Indeed, it catalyzes the demethylation of both histone H3 Lysine 9 (H3K9me3) and Lysine 36 (H3K36me3) by hydroxylation of the lysine methyl group leading to a dissociation of the methyl group from the lysine histone tail. KDM4C employs 2-oxoglutarate (OG), Fe2+ and oxygen as cosubstrates to promote its enzymatic reaction, thus the dissociation of methyl groups.
 == Structural highlights ==