Sandbox Reserved 1491: Difference between revisions

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KDM4C is involved in carcinogenesis as an oncogene. Indeed, by catalyzing the demethylation of H3K9-me3 (lysine 9 from trimethylated histones 3) to H3K9-me2 (lysine 9 from dimethylated histones 3), this protein increases the expression of its target genes. Several KDM4C target genes are involved in cell growth. For example, they influence mitogenic signalling - which promotes mitosis and cell division -, cell cycle regulation and translation.

KDM4C is involved in carcinogenesis as an oncogene. Indeed, by catalyzing the demethylation of H3K9-me3 (lysine 9 from trimethylated histones 3) to H3K9-me2 (lysine 9 from dimethylated histones 3), this protein increases the expression of its target genes. Several KDM4C target genes are involved in [https://en.wikipedia.org/wiki/Cell_growth cell growth]. For example, they influence mitogenic signalling - which promotes mitosis and cell division -, cell cycle regulation and translation.

In cancer cells, KDM4C expression is enhanced. Thus, the growth of tumor cells is greatly increased. <ref>Gregory, Brittany L., and Vivian G. Cheung. ‘Natural Variation in the Histone Demethylase, KDM4C, Influences Expression Levels of Specific Genes Including Those That Affect Cell Growth’. Genome Research 24, no. 1 (January 2014): 52–63. https://doi.org/10.1101/gr.156141.113</ref>

Sandbox Reserved 1491: Difference between revisions

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Revision as of 15:16, 10 January 2019 view source Emeric Goetz (talk \| contribs) 67 edits No edit summary ← Older edit		Revision as of 15:17, 10 January 2019 view source Emeric Goetz (talk \| contribs) 67 edits No edit summary Newer edit →
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	KDM4C is involved in carcinogenesis as an oncogene. Indeed, by catalyzing the demethylation of H3K9-me3 (lysine 9 from trimethylated histones 3) to H3K9-me2 (lysine 9 from dimethylated histones 3), this protein increases the expression of its target genes. Several KDM4C target genes are involved in cell growth. For example, they influence mitogenic signalling - which promotes mitosis and cell division -, cell cycle regulation and translation.		KDM4C is involved in carcinogenesis as an oncogene. Indeed, by catalyzing the demethylation of H3K9-me3 (lysine 9 from trimethylated histones 3) to H3K9-me2 (lysine 9 from dimethylated histones 3), this protein increases the expression of its target genes. Several KDM4C target genes are involved in [https://en.wikipedia.org/wiki/Cell_growth cell growth]. For example, they influence mitogenic signalling - which promotes mitosis and cell division -, cell cycle regulation and translation.
	In cancer cells, KDM4C expression is enhanced. Thus, the growth of tumor cells is greatly increased. <ref>Gregory, Brittany L., and Vivian G. Cheung. ‘Natural Variation in the Histone Demethylase, KDM4C, Influences Expression Levels of Specific Genes Including Those That Affect Cell Growth’. Genome Research 24, no. 1 (January 2014): 52–63. https://doi.org/10.1101/gr.156141.113</ref>		In cancer cells, KDM4C expression is enhanced. Thus, the growth of tumor cells is greatly increased. <ref>Gregory, Brittany L., and Vivian G. Cheung. ‘Natural Variation in the Histone Demethylase, KDM4C, Influences Expression Levels of Specific Genes Including Those That Affect Cell Growth’. Genome Research 24, no. 1 (January 2014): 52–63. https://doi.org/10.1101/gr.156141.113</ref>