Sandbox Reserved 1490: Difference between revisions
From Proteopedia
Jump to navigationJump to search
No edit summary |
No edit summary |
||
| Line 39: | Line 39: | ||
This is a sample scene created with SAT to <scene name="/12/3456/Sample/1">color</scene> by Group, and another to make <scene name="/12/3456/Sample/2">a transparent representation</scene> of the protein. You can make your own scenes on SAT starting from scratch or loading and editing one of these sample scenes. | This is a sample scene created with SAT to <scene name="/12/3456/Sample/1">color</scene> by Group, and another to make <scene name="/12/3456/Sample/2">a transparent representation</scene> of the protein. You can make your own scenes on SAT starting from scratch or loading and editing one of these sample scenes. | ||
===Catalytic activation | ===Catalytic activation === | ||
ATP + L-tyrosyl-[protein] = ADP + H+ + O-phospho-L-tyrosyl-[protein] | ATP + L-tyrosyl-[protein] = ADP + H+ + O-phospho-L-tyrosyl-[protein] | ||
Angiopoietin binding leads to receptor dimerization and activation by autophosphorylation at Tyr-992 on the kinase activation loop. | Angiopoietin binding leads to receptor dimerization and activation by autophosphorylation at Tyr-992 on the kinase activation loop. | ||
| Line 47: | Line 47: | ||
===Description of total protein=== | ===Description of total protein=== | ||
[[Image:TIE2 Schema.jpg]] | [[Image:TIE2 Schema.jpg]] | ||
====Important sites: ==== | ====Important sites :==== | ||
AA= Amino Acid | AA= Amino Acid | ||
| Line 80: | Line 80: | ||
– AA 824 to 1096: Protein kinase | – AA 824 to 1096: Protein kinase | ||
===Secondary structure | ===Secondary structure === | ||
{| class="wikitable" | {| class="wikitable" | ||
| Line 191: | Line 191: | ||
– Modified residue: Phosphotyrosine 1108 | – Modified residue: Phosphotyrosine 1108 | ||
===Sequence | ===Sequence === | ||
Due to alternative splicing, several sequences are possible for the protein. There are therefore several isoforms, here we show isoform 1 chosen as the canonical sequence. | Due to alternative splicing, several sequences are possible for the protein. There are therefore several isoforms, here we show isoform 1 chosen as the canonical sequence. | ||
