Sandbox Reserved 1490: Difference between revisions
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===• | ===• Others amino acid modifications=== | ||
{| class="wikitable" | |||
|- | |||
! Type of modification | |||
! AA position | |||
|- | |||
| Phosphotyrosine | |||
| 860 | |||
|- | |||
| Phosphotyrosine | |||
| 992 | |||
|- | |||
| Phosphotyrosine | |||
| 1102 | |||
|- | |||
| Phosphotyrosine | |||
| 1108 | |||
|} | |||
===• Sequence === | ===• Sequence === | ||
| Line 230: | Line 241: | ||
– '''Mutation in position 897''' : Tyrosine → Cystéine. Change from large size and aromatic (Y) to medium size and polar (C). An error of vascular morphogenesis characterized by dilated, serpiginous channels | – '''Mutation in position 897''' : Tyrosine → Cystéine. Change from large size and aromatic (Y) to medium size and polar (C). An error of vascular morphogenesis characterized by dilated, serpiginous channels | ||
– '''Mutation in position 897''' : Tyrosine → Sérine. Change from large size and aromatic (Y) to small size and polar (S). An error of vascular morphogenesis characterized by dilated, serpiginous channels. | – '''Mutation in position 897''' : Tyrosine → Sérine. Change from large size and aromatic (Y) to small size and polar (S). An error of vascular morphogenesis characterized by dilated, serpiginous channels. | ||
– '''Mutation in position 915''' : Arginine → Histidine. Change from large size and basic (R) to medium size and polar (H). An error of vascular morphogenesis characterized by dilated, serpiginous channels. | – '''Mutation in position 915''' : Arginine → Histidine. Change from large size and basic (R) to medium size and polar (H). An error of vascular morphogenesis characterized by dilated, serpiginous channels. | ||
– '''Mutation in position 918''' : Arginine → Cystéine. Change from large size and basic (R) to medium size and polar (C). An error of vascular morphogenesis characterized by dilated, serpiginous channels. | – '''Mutation in position 918''' : Arginine → Cystéine. Change from large size and basic (R) to medium size and polar (C). An error of vascular morphogenesis characterized by dilated, serpiginous channels. | ||
– '''Mutation in position 919''' : Valine → Leucine. Similar physico-chemical property. Both residues are medium size and hydrophobic. An error of vascular morphogenesis characterized by dilated, serpiginous channels. | – '''Mutation in position 919''' : Valine → Leucine. Similar physico-chemical property. Both residues are medium size and hydrophobic. An error of vascular morphogenesis characterized by dilated, serpiginous channels. | ||
– '''Mutation in position 925''' : Alanine → Sérine. Change from small size and hydrophobic (A) to small size and polar (S). Increased ligand-independent autophosphorylation and kinase activation. | – '''Mutation in position 925''' : Alanine → Sérine. Change from small size and hydrophobic (A) to small size and polar (S). Increased ligand-independent autophosphorylation and kinase activation. | ||
– '''Mutation in position 1100''' : Lysine → Asparagine. Change from large size and basic (K) to medium size and polar (N). Increased ligand-independent autophosphorylation and kinase activation. | – '''Mutation in position 1100''' : Lysine → Asparagine. Change from large size and basic (K) to medium size and polar (N). Increased ligand-independent autophosphorylation and kinase activation. | ||
===•Mutagenesis=== | |||
– '''Mutation in position 855''': Loss of kinase activity | |||
– '''Mutation in position 1102''': Removes interaction with CHS1 | |||
== Medical relevance == | == Medical relevance == | ||
