Sandbox Reserved 1502: Difference between revisions
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The new experimental antirviral, here the (6-chloro-2-oxo-4-phenyl-1,2-dihydroquinolin-3-yl)acetic acid, interacts with the site with which <scene name='80/802676/Site_of_interaction/7'>the cofactor bind with the LEDGF/p75 cofactor</scene>. This site is situated in the core domain. | The new experimental antirviral, here the (6-chloro-2-oxo-4-phenyl-1,2-dihydroquinolin-3-yl)acetic acid, interacts with the site with which <scene name='80/802676/Site_of_interaction/7'>the cofactor bind with the LEDGF/p75 cofactor</scene>. This site is situated in the core domain. | ||
The molecule then inhibits the interaction between the LEDGF/p75 cofactor and the integrase. | The molecule then inhibits the interaction between the LEDGF/p75 cofactor and the integrase. | ||
The whole complex between the integrase and the cofactor is displyed on the proteopedia page [[2B4J]]. | |||
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https://www-nature-com.scd-rproxy.u-strasbg.fr/articles/nchembio.370 | https://www-nature-com.scd-rproxy.u-strasbg.fr/articles/nchembio.370 | ||
https://www.uniprot.org/uniprot/Q76353#sequences | https://www.uniprot.org/uniprot/Q76353#sequences | ||
http://pfam.xfam.org/family/rve | |||
http://pfam.xfam.org/protein/Q76353_9HIV1 | |||
https://www.rcsb.org/3d-view/3LPT/1 | |||
https://en.wikipedia.org/wiki/Diethylene_glycol | |||
https://microbewiki.kenyon.edu/index.php/HIV-1_Pre-Integration_Complex | |||
https://www.uniprot.org/uniprot/Q76353 | |||
https://www.rcsb.org/structure/3lpt | |||
http://proteopedia.org/wiki/index.php/Retroviral_Integrase | |||
<references/> | <references/> | ||
