Sandbox Reserved 1502: Difference between revisions
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The new experimental antirviral, here the (6-chloro-2-oxo-4-phenyl-1,2-dihydroquinolin-3-yl)acetic acid, interacts with the site with which <scene name='80/802676/Site_of_interaction/7'>the cofactor bind with the LEDGF/p75 cofactor</scene>. This site is situated in the core domain. | The new experimental antirviral, here the (6-chloro-2-oxo-4-phenyl-1,2-dihydroquinolin-3-yl)acetic acid, interacts with the site with which <scene name='80/802676/Site_of_interaction/7'>the cofactor bind with the LEDGF/p75 cofactor</scene>. This site is situated in the core domain. | ||
The molecule then inhibits the interaction between the LEDGF/p75 cofactor and the integrase. | The molecule then inhibits the interaction between the LEDGF/p75 cofactor and the integrase. | ||
The whole complex between the integrase and the cofactor is | The whole complex between the integrase and the cofactor is displayed on the proteopedia page [[2b4j]]. | ||
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<scene name='80/802676/Hiv_integrase_3lpt/8'>HIV Integrase 3lpt</scene> | <scene name='80/802676/Hiv_integrase_3lpt/8'>HIV Integrase 3lpt</scene> | ||
==See also== | |||
http://proteopedia.org/wiki/index.php/2b4j :integrase ligated with the cofactor LEDGF/p75 | |||
== References == | == References == | ||
https://www.hiv.gov/hiv-basics/overview/about-hiv-and-aids/what-are-hiv-and-aids | https://www.hiv.gov/hiv-basics/overview/about-hiv-and-aids/what-are-hiv-and-aids | ||
