Sandbox Reserved 1502: Difference between revisions
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[[Image:HIV Integrase sequence.jpg]] | [[Image:HIV Integrase sequence.jpg]] | ||
====Structure and role of the N ter domain==== | |||
The N-terminal domain of HIV-1 integrase contains a conserved pair of His and Cys residues, a motif similar to the zinc-coordinating residues of zinc fingers. This domain does bind zinc but its structure is totally different from that of zinc fingers. It consists of a bundle of three α-helices. It has an SH3 fold, although there is no known functional relationship with the SH3 domains of other proteins. | |||
[[Image:N ter domain.jpg]] | |||
====Structure and interaction with the antiviral==== | ====Structure and interaction with the antiviral==== | ||
