Sandbox Reserved 1502: Difference between revisions

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== Interaction with LEDGF/p75 and antiviral ==
== Interaction with LEDGF/p75 and antiviral ==


Research on HIV show that the integrase use a protein, the LEDGF/p75 cofactor, so as to the preintegration complex is ligated to the DNA.  
Research on HIV shows that the integrase uses a protein, the LEDGF/p75 cofactor, to ligate the preintegration complex to the DNA.  
Some recents experimental antiviral inhibe this interaction and unable the integrase to interact with the cofactor. Thus, the DNA wouldn’t be inserted into the genome of the cell.
Some recent experimental antiviral inhibits this interaction and unable the integrase to interact with the cofactor. Thus, the DNA wouldn’t be inserted into the genome of the cell.




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[[Image:Core enzyme.jpg]]
[[Image:Core enzyme.jpg]]
<scene name='80/802676/Core_enzyme/1'>Here is the 3D structure of the core domain</scene>


====Structure and role of the N ter domain====
====Structure and role of the N ter domain====
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====Structure and interaction with the antiviral====
====Structure and interaction with the antiviral====


The new experimental antirviral, here the (6-chloro-2-oxo-4-phenyl-1,2-dihydroquinolin-3-yl)acetic acid, interacts with the site with which <scene name='80/802676/Site_of_interaction/7'>the cofactor bind with the LEDGF/p75 cofactor</scene>. This site is situated in the core domain.
The new experimental antiviral, here the (6-chloro-2-oxo-4-phenyl-1,2-dihydroquinoline-3-yl)acetic acid, interacts with the site with which <scene name='80/802676/Site_of_interaction/7'>the cofactor bind with the LEDGF/p75 cofactor</scene>. This site is situated in the core domain.
The molecule then inhibits the interaction between the LEDGF/p75 cofactor and the integrase.
The molecule then inhibits the interaction between the LEDGF/p75 cofactor and the integrase.
The whole complex between the integrase and the cofactor is displayed on the proteopedia page [[2b4j]].
The whole complex between the integrase and the cofactor is displayed on the Proteopedia page [[2b4j]].




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== Disease: AIDS ==
== Disease: AIDS ==


AIDS is the ultimate stage of infection with the human immunodeficiency virus. The word AIDS stands for for Acquired Immunodeficiency Syndrome. People with AIDS get an increasing number of severe illnesses, called opportunistic infections, because of there damaged immune system. You are considered to have progressed to AIDS when the number of your CD4 cells falls below 200 cells per cubic millimeter of blood (200 cells/mm3). (In someone with a healthy immune system, CD4 counts are between 500 and 1,600 cells/mm3.) You are also considered to have progressed to AIDS if you develop one or more opportunistic illnesses, regardless of your CD4 count.[https://www.hiv.gov/hiv-basics/overview/about-hiv-and-aids/what-are-hiv-and-aids]
AIDS is the ultimate stage of infection with the human immunodeficiency virus. The word AIDS stands for Acquired Immunodeficiency Syndrome. People with AIDS get an increasing number of severe illnesses, called opportunistic infections, because of there damaged immune system. You are considered to have progressed to AIDS when the number of your CD4 cells falls below 200 cells per cubic millimeter of blood (200 cells/mm3). (In someone with a healthy immune system, CD4 counts are between 500 and 1,600 cells/mm3.) You are also considered to have progressed to AIDS if you develop one or more opportunistic illnesses, regardless of your CD4 count.[https://www.hiv.gov/hiv-basics/overview/about-hiv-and-aids/what-are-hiv-and-aids]




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