Sandbox Reserved 1493: Difference between revisions
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Extracellular proteins such as fibrinogen enables platelets aggregation and clotting. Integrin αIIbβ3 also bridges to other αIIbβ3 of adjacent platelets. | Extracellular proteins such as fibrinogen enables platelets aggregation and clotting. Integrin αIIbβ3 also bridges to other αIIbβ3 of adjacent platelets. | ||
Activation mostly occurs via modulation of affinity, but is also affected by avidity for ligand due to receptor clustering by multivalent ligands and changes in membrane fluidity. | |||
=== Responses: outside-in signaling from the headpiece === | === Responses: outside-in signaling from the headpiece === | ||
