Sandbox Reserved 1502: Difference between revisions
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<StructureSection load='3lpt' size='340' side='right' caption='[[3lpt]], [[Resolution|resolution]] 2.00Å' scene=''> | <StructureSection load='3lpt' size='340' side='right' caption='[[3lpt]], [[Resolution|resolution]] 2.00Å' scene=''> | ||
3lt is an integrase of the HIV, the Human Immunodeficiency Virus. An integrase is an enzyme produced by a retrovirus to integrate its genetic material into the DNA of the infected cell. It is one of three enzymes of HIV, the others being the Reverse Transcriptase and the Protease. | The 3lt is an integrase of the HIV, the Human Immunodeficiency Virus. An integrase is an enzyme produced by a retrovirus to integrate its genetic material into the DNA of the infected cell. It is one of three enzymes of HIV, the others being the Reverse Transcriptase and the Protease. | ||
== Structural highlights == | == Structural highlights == | ||
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Length:288, Mass (Da):32,199 | Length:288, Mass (Da):32,199 | ||
'''Sequence | '''Sequence chain view of the HIV Integrase:''' | ||
[[Image:HIV Integrase sequence.jpg]] [http://www.rcsb.org/pdb/explore/remediatedSequence.do?structureId=3lpt] | [[Image:HIV Integrase sequence.jpg]] [http://www.rcsb.org/pdb/explore/remediatedSequence.do?structureId=3lpt] | ||
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====Use of antiviral to inhibit the LEDGF/p75-integrase interaction ==== | ====Use of antiviral to inhibit the LEDGF/p75-integrase interaction ==== | ||
An antiviral refers to a molecule disrupting the replication cycle of one or more viruses, thus allowing to slow down but rarely to stop a viral infection. Antiviral targeting specific regions of the integrase are used to prevent the replication of HIV. For example, the 2-(quinolin-3-yl)acetic acid interacts with <scene name='80/802676/Site_of_interaction/7'>the binding site of the LEDGF/p75 cofactor</scene>. More precisely, it binds to the residues E170, H171 and T174. This site is situated in the core domain of the enzyme. Once it is fixed into the core domain, the LEDGF/p75 will not be able to join and viral integration of the retrovirus will not be possible anymore. | An antiviral refers to a molecule disrupting the replication cycle of one or more viruses, thus allowing to slow down but rarely to stop a viral infection. Antiviral targeting specific regions of the integrase are used to prevent the replication of HIV. For example, the 2-(quinolin-3-yl)acetic acid interacts with <scene name='80/802676/Site_of_interaction/7'>the binding site of the LEDGF/p75 cofactor</scene>. More precisely, it binds to the residues E170, H171, and T174. This site is situated in the core domain of the enzyme. Once it is fixed into the core domain, the LEDGF/p75 will not be able to join and viral integration of the retrovirus will not be possible anymore. | ||
The whole complex between the integrase and the cofactor is displayed on the Proteopedia page [[2b4j]]. | The whole complex between the integrase and the cofactor is displayed on the Proteopedia page [[2b4j]]. | ||
