Sandbox Reserved 1493: Difference between revisions
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The '''headpiece''' (2VDL) of integrin αIIbβ3 enables cation-facilitated ligand binding with multiple ligands (most known being [[fibrinogen]], [[fibronectin]], von Willebrand factors, [[thrombospondin]] and vitronectin). Binding affinity is dynamic and depends on the conformational status of the receptor. | The '''headpiece''' (2VDL) of integrin αIIbβ3 enables cation-facilitated ligand binding with multiple ligands (most known being [[fibrinogen]], [[fibronectin]], von Willebrand factors, [[thrombospondin]] and vitronectin). Binding affinity is dynamic and depends on the conformational status of the receptor. | ||
''Jmol displays residues 32-483 of αIIb and residues 27-487 of β3. In order to have a global view and better comprehension of the molecule, refer to pictures.'' | |||
<StructureSection load='2vdl' size='340' side='right' caption='2VDL Headpiece of integrin αIIbβ3' scene=''> | <StructureSection load='2vdl' size='340' side='right' caption='2VDL Headpiece of integrin αIIbβ3' scene=''> | ||
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Ligands bind in a groove between the integrin subunits, at the intersection of the integrin extracellular '''β-propeller of the αIIb subunit''' and the '''β I domain of the β3 subunit'''. There are multiple binding sites in both subunits. | Ligands bind in a groove between the integrin subunits, at the intersection of the integrin extracellular '''β-propeller of the αIIb subunit''' and the '''β I domain of the β3 subunit'''. There are multiple binding sites in both subunits. | ||
=== αIIb subunit === | === αIIb subunit === | ||
